Why can't you lose weight even if you diet or exercise? -- A new generation of weight loss solutions recommended by doctors

Have you ever had this experience: counting calories every day, exercising regularly, and being too hungry to sleep at night, but after a month, your weight doesn't move at all? What's worse, once you resume your normal diet, your weight rebounds faster than you lose it ?

This is not because you are not working hard enough, but because you, like most people, have overlooked the core role of " metabolism " and " hormone regulation " in weight loss . What really prevents you from losing weight is often not calories, but insulin resistance, appetite hormone disorders and decreased basal metabolism .

 

1. Why do traditional diets and exercise often fail?

📌 1.1 The pitfalls of dieting

•       Reduced calorie intake → the body automatically reduces metabolism → " The longer you diet, the slower you lose weight "

•       As fat is reduced, muscle is also lost , causing basal metabolism to further decrease.

📌 1.2 Exercise weight loss is difficult to maintain in the long term

•       Requires long-term and high-frequency persistence

•       For obese people, exercise itself does not consume much calories and weight loss is slow.

📌 1.3 Hormone imbalance is the key

•       Insulin resistance makes fat easier to store and harder to break down

•       An imbalance in appetite hormones (such as ghrelin and leptin ) can make you feel " unexplainedly hungry "

 

2. A new generation of solutions recommended by doctors: telpotide

Tipoline ( Mounjaro/Zepbound ) is a GLP-1 + GIP dual agonist approved by the FDA for the management of diabetes and obesity in 2022. It fundamentally regulates the body's energy metabolism mechanism by activating two intestinal hormone receptors:

Mechanism of action	Specific manifestations
Suppress appetite	Acts on the hypothalamic appetite center to naturally reduce hunger
Delays gastric emptying	Increase the time you spend full and actively reduce the amount you eat
Promotes fat burning	Activate the GIP pathway, promote fat oxidation, and decompose visceral fat
Improved insulin sensitivity	Reduce blood sugar fluctuations and avoid the vicious cycle of obesity → insulin → obesity

3. Clinical research: Why is tepote called the “ strongest weight loss drug ” ?

📌 SURMOUNT-1 clinical trial results ( 72 weeks)

•       Average weight loss: 22.5%

•       Proportion of people who lost ≥20% of their body weight: more than 57%

•       Surpassing semaglutide ( Wegovy )'s 16.9% , becoming the most effective weight loss drug currently

In addition, tebuconazole is also superior in improving blood sugar, visceral fat, and insulin levels , and is more suitable for long-term users and people with metabolic abnormalities.

 

4. Who is suitable for using telpotide?

📌 Recommended for:

•       BMI ≥30 Moderate to severe obesity

•       BMI ≥27 and comorbid metabolic problems (such as diabetes, fatty liver, insulin resistance)

•       Those who have tried dieting and exercise but have not seen any results or have rebounded

📌 Taboo people:

•       A family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome ( MEN2 )

•       Pregnant women and breastfeeding women

•       Severe gastrointestinal motility disorders (such as gastroparesis)

 

5. How to get started? Key steps to a safe start

📌 Starting plan suggestions:

•       Use 2.5 mg for the first 4 weeks as an adaptation period

•       Increase the dose every 4 weeks (to 5 mg , 10 mg , and finally 15 mg )

•       Injecting after meals, eating a light diet, and avoiding high-fat foods can significantly reduce side effects

 

Conclusion: Losing weight does not depend on endurance, but on the right method

There is nothing wrong with dieting and exercise, but for people with hormonal disorder-type obesity, they are only " treating the symptoms but not the root cause " . By regulating appetite and fat metabolism mechanisms, telportin breaks the hormonal barriers behind obesity and provides a stable, safe and sustainable medical solution for long-term weight loss.

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