A complete analysis of the new anti-insomnia drug Lebrexan
In the fast-paced modern life, insomnia is becoming more and more common. According to the "White Paper on Chinese Residents' Health" released by the China Sleep Research Society, 60% of Chinese people are troubled by the anxiety of insomnia. Today, we are going to discuss a new anti-insomnia drug that has attracted much attention - Lemborexant (trade name Dayvigo).
1. Mechanism of Action
The mechanism of action of Lebrexan is very different from that of traditional sedative sleeping pills. It mainly blocks the binding of orexin to orexin receptors, reduces the transmission of wakefulness signals in the brain, just like pressing the pause button on the "wakefulness switch" in the brain, helping patients fall asleep more easily and maintain a stable sleep state. This unique mode of action makes it have its own "secret recipe" in treating insomnia.
2. Applicable groups
Lebrexan is mainly suitable for adult insomniacs who suffer from both difficulty falling asleep and difficulty maintaining sleep. It may work whether the insomnia is caused by great psychological pressure, sudden changes in the environment, or some minor physiological conditions. For example, many office workers have difficulty falling asleep at night because of work pressure, tossing and turning in bed, or waking up frequently at night. Lebrexan may become their savior; there are also some elderly people who have poor sleep quality and are often troubled by sleep segmentation problems. Lebrexan can also help them get a more continuous night's rest.
3. Unique advantages
- No dependence, no addiction : Compared with traditional benzodiazepines, Lebrexan is more selective. It mainly targets orexin receptors and will not directly interfere with other neurotransmitter systems. It will not make patients dependent on drugs like traditional sleeping pills. This allows patients who suffer from insomnia for a long time to use it with more peace of mind.
- Significant and lasting efficacy : In clinical studies, Lebrexan performed well and significantly improved insomnia symptoms. Moreover, this good efficacy can still be maintained after 12 months of continuous use, truly achieving long-term sleep assistance.
- Little impact on respiratory function : For some patients with impaired respiratory function, they are always cautious when choosing sleep aids, fearing that they will affect their breathing. However, Lebrexan has little impact on respiratory function, making it a safe choice for such patients to treat insomnia.
- Does not affect next-day function : After taking Lebrosen, patients do not have to worry about feeling groggy the next day. It has minimal residual effect on morning alertness and next-day normal function. Patients can respond to external auditory stimuli in the middle of the night and can still work and live energetically the next day.
- Reasonable price : Although it is a new drug, the price of Lebrexan is within the acceptable range for patients. Lebrexan produced by Japan Eisai has different specifications. The reference price of 10mg Debigo tablets is about US$165; the reference price of 5mg Debigo tablets is about US$115; the reference price of 2.5mg Debigo tablets is about US$76. Although the prices of different specifications fluctuate due to market factors, the overall cost performance is good.
IV. Adverse Reactions and Precautions
- Adverse reactions :
- Drowsiness and fatigue : These are common reactions that may affect patients' daily life and work, especially for patients taking a 10 mg dose, whose driving ability may be impaired.
- Sleep paralysis : During the sleep-wake transition, the patient may be unable to move or speak for up to several minutes.
- Complex sleep behaviors : Sleepwalking and engaging in other activities while not fully awake may occur, and patients usually have no memory of these behaviors.
- Symptoms similar to mild cataplexy : Leg weakness may last from seconds to minutes, may occur at night or during the day, and may not be related to a specific triggering event.
- Worsened Depression/Suicidal Ideation : Worsened depression and suicidal thoughts and behavior have been reported in some patients, particularly those with primary depression who were treated with hypnotics.
- Note :
- Central nervous system depression : Lebrexan is a central nervous system depressant that may impair daytime wakefulness even when used as prescribed, and this depressant effect may persist for several days after some patients stop taking the drug. Therefore, doctors should inform patients of the possibility of drowsiness the next day, and patients taking 10 mg should be especially careful to avoid driving and activities that require high mental alertness. At the same time, it is not recommended to use it in combination with other central nervous system depressants, and do not drink alcohol at the same time.
- Special populations : When used by patients with impaired respiratory function, the impact on respiratory function should be considered; patients with depressive symptoms need to be closely monitored when used because they may have suicidal tendencies. Once new behavioral signs or symptoms appear, they need to be carefully evaluated immediately.
- Storage conditions : Lebrexan should be stored at 20°C - 25°C. Avoid exposure to extreme temperatures and keep away from light to prevent adverse effects on the drug.
As a new anti-insomnia drug, Lebrexan has brought new hope to many insomnia patients. However, before using it, you must learn about its relevant information in detail and strictly follow the doctor's advice and guidance, so that you can improve your sleep while ensuring your health and safety. I hope that every friend who is troubled by insomnia can find a good sleep remedy that suits them as soon as possible and sleep well every night.
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