Tipoline vs. semaglutide: Which is right for you?
With the development of medical weight loss drugs, GLP-1 receptor agonists have gradually become the mainstream choice for obese people. Among them, semaglutide is widely used due to its significant weight loss effect, while the more advanced GLP-1/GIP dual agonist telpotide stands out in clinical studies with its stronger weight loss ability.
Both drugs are injectable weight loss drugs and have been approved by the FDA , but they differ significantly in their mechanism of action, weight loss speed, side effects, and applicable populations. This article will help you make a scientific judgment through clinical data comparison: which drug is more suitable for you?
1. Comparison of drug action mechanisms: single agonist vs. dual agonist
|
Dimensions |
Telportide |
Semaglutide |
|
Agonist type |
GLP-1 + GIP dual agonist |
GLP-1 single agonist |
|
Target |
Appetite center, pancreatic β cells, adipocytes |
Appetite center, gastric emptying regulation |
|
Mechanism characteristics |
Suppress appetite + promote fat decomposition + improve insulin sensitivity |
Suppress appetite + delay gastric emptying |
|
Metabolic regulation ability |
Strong (can improve blood sugar and insulin resistance) |
medium |
📌 Summary : Through a dual agonist mechanism, tepote not only suppresses appetite more strongly, but also actively stimulates fat decomposition and optimizes metabolic status , with a more comprehensive mechanism of action.
2. Weight loss effect comparison: Who is faster? Who is more stable?
Tipollution ( SURMOUNT-1 study, 72 weeks)
• Average weight loss 22.5%
• More than 57% of people lost ≥20% of their body weight
• Maximum weight loss can reach 27%
Semaglutide ( STEP-1 study, 68 weeks)
• Average weight loss : 16.9%
• About 36% of people lost ≥20% of their body weight
• The maximum weight loss is about 18%
📌 Summary : Under similar usage cycles, the weight loss effect of tebuconazole is significantly stronger and faster, and it is more friendly to people with heavy weight .
3. Side effects and tolerance: Which drug is milder?
|
Types of side effects |
telpotide ( Mounjaro ) |
semaglutide ( Wegovy ) |
|
nausea |
31% |
44% |
|
Vomit |
18% |
twenty four% |
|
diarrhea |
twenty one% |
30% |
|
constipate |
14% |
17% |
|
fatigue |
7% |
10% |
📌 Summary : Telpotide can partially neutralize the gastrointestinal irritation caused by GLP-1 due to its GIP component . In clinical manifestations, gastrointestinal discomfort is milder and its tolerability is better than semaglutide , making it more suitable for long-term use.
4. Comparison of applicable groups: Which one is suitable for you?
|
Demographic characteristics |
Recommended drugs |
Reason |
|
BMI ≥30 , need to lose weight quickly and significantly |
Telportide |
Large weight loss at a fast speed |
|
BMI ≥27 , with metabolic problems such as diabetes and fatty liver |
Telportide |
Lower blood sugar and improve metabolic capacity |
|
Sensitivity to side effects of injectable medications |
Telportide |
Better gastrointestinal tolerance |
|
The goal is mild weight loss with manageable side effects |
Semaglutide |
Patients who can tolerate mild discomfort |
|
If your budget is limited, try GLP-1 drugs first |
Semaglutide |
The market price is slightly lower than that of telportin |
5. Telbutide vs. semaglutide: How to choose?
📌 Telportide is more suitable for:
• Want to lose more than 15% weight, especially those with a BMI ≥35
• Have health problems such as metabolic syndrome and prediabetes
• Those who want to use it for a long time and have concerns about side effects
📌 Semaglutide is more suitable for:
• Aim for moderate weight loss ( 10%-15% )
• People who want to try the GLP-1 starter version and have price considerations
💡 Conclusion : Telpotide is superior to semaglutide in weight loss effect and tolerability, and is currently the most cost-effective weight loss injection.
🛒Mounjaro 2.5mg *2 sticks / box *2
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