The sleeping pills suitable for parents are not the more sedative the better, but "naturally falling asleep and naturally waking up"
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1. Parents’ insomnia is not because they are not sleepy, but because they cannot sleep well .
Many middle-aged and elderly people will say: " I wake up at around 3 o'clock " or " Old people just sleep lightly ." However, medical research shows that this is not inevitable due to natural aging, but a disorder of sleep structure:
• Less deep sleep (shorter N3 stage)
• Lowered arousal threshold (wakes up at the slightest movement)
• Reduced melatonin secretion and circadian rhythm dislocation
• At the same time, a variety of chronic diseases / drug interference also affect sleep
📌 Many parents feel tired during the day, not because they are “ old ” , but because they do not get enough “ quality ” sleep .
2. Traditional sleeping pills: Quick sedation, but may bring greater risks
Most of the old-school sleeping pills (such as diazepam, zopiclone, etc.) that are still common on the market belong to benzodiazepines or their derivatives , and their characteristics are:
• Directly suppress the brain by activating GABA-A receptors
• It is easy to form drug dependence , and the more you take, the more you eat
• Rebound insomnia, anxiety, and cognitive decline after drug withdrawal
• 📌 A French cohort study showed that the risk of developing Alzheimer's disease increased by 50% in elderly people who used benzodiazepines for a long time ( Billioti de Gage et al., 2014 )
In addition, drugs with strong sedative effects can also affect the reaction and balance when getting up in the morning , increase the risk of falling, and are extremely unfriendly to middle-aged and elderly people .
3. ORAs: No sedation, no addiction, easier to wake up
ORAs , such as suvorexant, lebrexant, and darilexant , are a new generation of options that are more suitable for middle-aged and elderly people:
characteristic |
Advantages |
✅ Mechanism of action |
Inhibiting the orexin system reduces arousal signals rather than calming the brain |
✅ Sleep structure |
Does not interfere with N3 and REM phases, promoting deep restorative sleep |
✅ Next day status |
Moderate half-life, no residue, no dizziness, no sluggishness |
✅ Security |
No dependence, no rebound after stopping the drug, suitable for staged use or long-term adjustment |
📌 Research confirms that:
• Suvorexant : No effect on cognition in people over 60 years old ( Michelson et al., 2014 )
• Daleleisin : After long-term use, you can still maintain high response ability in the morning without hangover ( Muehlan et al., 2022 )
• Lebrexan : After 6 months of continuous use, sleep rhythm remained stable after drug withdrawal ( Ueno et al., 2022 )
4. If you are choosing sleeping pills for your parents, please remember these points:
• ❌ Don’t seek to “ sleep quickly ” , but to “ sleep steadily ”
• ❌ Not for sedation, but for rhythm regulation
• ✅ It would be best if it does not affect memory, does not increase the risk of falling, and does not need to be taken every day
• ✅ Able to adapt to the rhythm of life (such as taking a lunch break, taking care of grandchildren, and morning exercise) without affecting daytime performance
These three ORAs are excellent solutions to these problems.
Conclusion: Helping parents choose sleeping pills is like choosing shoes - the most important thing is whether they fit well
The sleep of parents cannot be solved by " calming them down " . The medicine that is truly suitable for them should let them fall asleep naturally, stay up all night, wake up refreshed, and do what they like during the day. Suvorexant, Lebrexant, and Dalirexant are scientific tools designed for such a lifestyle. It is not to make parents " fall asleep " , but to help them " come back to sleep " . This sleep is good and more peaceful.
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