Helping you sleep without harming your body, and gently regulating your sleep rhythm, how safe are these 3 drugs?
1. Insomnia in modern society: Why is safe sleep aid so important?
The fast-paced life, long-term use of electronic screens, and high-pressure working environment in modern society are making insomnia an increasingly common health problem . According to data from the World Health Organization ( WHO ), about 35% of adults worldwide are affected by sleep disorders, of which 10% suffer from chronic insomnia ( Morin et al., 2020 ). Long-term insomnia not only leads to decreased memory, weakened immunity, and increased risk of anxiety and depression , but is also closely related to hypertension, diabetes, and cardiovascular disease ( Krystal et al., 2019 ).
For many insomnia patients, sleeping pills are a necessary intervention. However, traditional sleeping pills often cause side effects such as addiction, increased tolerance, and morning drowsiness , which makes many patients feel torn between improving sleep and avoiding side effects.
In recent years, a new generation of orexin receptor antagonists ( ORAs ) sleep aids (such as suvorexant, leborexant, and darilexant ) have gradually attracted attention. They do not force hypnosis by inhibiting the nervous system, but gently regulate wakefulness signals to allow the body to fall asleep naturally . Therefore, they are considered to be safer and more suitable for long-term use of sleep aids. So, how safe are these three drugs?
2. Limitations of traditional sleeping pills: Why are people looking for safer ways to help them sleep?
Traditional sleeping pills, such as benzodiazepines (such as diazepam) and non-benzodiazepines (such as zopiclone) , mainly act on GABA receptors and force people to fall asleep by inhibiting brain nerve activity. Although this method can be effective in the short term, long-term use often brings the following problems :
📌 Side effects of traditional sleeping pills :
• Easy to become addictive : Long-term use will cause the brain to become dependent, and the dosage must be gradually increased to maintain the effect ( Lader, 2011 ).
• Impact on cognitive function : Studies have found that long-term use of benzodiazepines increases the risk of Alzheimer’s disease by 50% ( Billioti de Gage et al., 2014 ).
• Morning sleepiness : Some sleeping pills have a long half-life, which can cause daytime fatigue and decreased concentration the next day ( Kuriyama & Endo, 2018 ).
• Sleep rebound after stopping medication : After stopping traditional sleeping pills, many patients experience insomnia symptoms that are even more severe than before taking the medication ( Lader, 2011 ).
For this reason, the medical community has been looking for safer, non-addictive sleeping aids . The new generation of orexin receptor antagonists (such as suvorexant, leporexant, and dalipoxant ) were created to solve this problem.
3. Orexin receptor antagonists ( ORAs ): Why are the new generation of sleeping aids safer?
Orexin is a neurotransmitter in the human body that helps maintain wakefulness . In a healthy sleep rhythm , orexin levels are high during the day and gradually decrease at night, allowing the brain to enter a sleep state. However, in insomniacs, the orexin system is often overactive, making it difficult for the brain to enter rest mode .
The mechanism of action of orexin receptor antagonists ( ORAs ) is different from that of traditional sleeping pills. They do not forcibly inhibit neural activity, but instead reduce the effects of orexin, allowing the body to fall asleep naturally .
📌 Advantages of the new generation of sleeping pills :
• Non-addictive and suitable for long-term use ( Sun et al., 2021 )
• Does not affect deep sleep, improving sleep quality ( Ueno et al., 2022 )
• There will be no withdrawal symptoms and sleep deterioration after stopping the drug ( Dauvilliers et al., 2022 )
• Will not affect cognitive function or cause morning drowsiness
The three main orexin receptor antagonists currently approved - suovoluxin, lebrexant and dalisant - have been clinically verified in terms of safety and effectiveness.
4. Comparison of the safety of three new sleeping pills
|
Drug Name |
Features |
Is it addictive? |
Does it affect cognition? |
Does it affect daytime status? |
|
Suvorexant |
Improve nighttime awakenings and help maintain stable sleep |
No dependencies |
No impact |
Possibly mild morning drowsiness |
|
Lemborexant |
Speed up falling asleep and adjust your biological clock |
No dependencies |
No impact |
Some people may experience mild drowsiness |
|
Daridorexant |
Improve deep sleep and wake up refreshed in the morning |
No dependencies |
No impact |
Does not affect daytime status |
From the comparison, it can be seen that the common characteristics of these three new sleeping pills are that they are non-addictive, do not affect cognitive function, and do not affect daytime wakefulness , so they are safer than traditional sleeping pills.
5. How to use sleeping pills scientifically to ensure safety?
Although new sleeping aids are safer, correct use is still the key to ensure effectiveness.
📌 Scientific medication recommendations: 💊 Recommended dosage : Depending on individual circumstances, suvorexant ( 10-20mg ), leborexant ( 5-10mg ), dalirexant ( 25mg ) , taken 30 minutes before bedtime. 💡 Note : Ensure at least 7 hours of sleep and avoid the simultaneous use of alcohol or other sedatives for best results. 📅 Integrate healthy sleep habits : reduce the use of electronic devices before bed, establish a regular schedule, and avoid caffeine and alcohol intake to improve overall sleep quality.
6. Helping you sleep without harming your body, why are these three medicines safer choices?
With the development of sleep science, new sleep-aiding drugs are gradually replacing traditional sleeping pills. Orexin receptor antagonists such as Suvorexant, Lebrexant, and Darilexant can help patients gently regulate their sleep rhythm without causing addiction risks, cognitive impairment, or morning sleepiness .
If your sleep problems include long-term difficulty falling asleep, waking up easily at night, and fatigue in the morning , then these three new sleeping pills may be a more scientific and safe choice .
🛒 Dayvigo lemborexant 2.5mg 100 tablets
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