Tirolamine vs. Traditional Weight Loss Pills: What's the Difference? Which Approach Is More Effective?

March 4, 2025

As weight management has become a global health concern, a variety of weight loss drugs have appeared on the market, from traditional appetite suppressants and fat absorption inhibitors to today's GLP-1 receptor agonists . Among them, tirpotide, as a GLP-1/GIP dual agonist, is considered to be one of the most effective weight loss solutions currently .

However, many people are still hesitant between traditional weight loss drugs and telolipoic acid, unsure which one is more suitable for them . This article will compare the differences between telolipoic acid and traditional weight loss drugs in detail from the aspects of mechanism of action, weight loss effect, side effects, long-term weight management , etc., to help you make a scientific choice.

1. Telpotide vs. Traditional Weight Loss Drugs: Comparison of Mechanisms of Action

category	Main representative drugs	Mechanism of action	Main Features
GLP-1/GIP agonist (Telportide)	Telportide	Through the action of GLP-1 and GIP , it reduces appetite, delays gastric emptying, and promotes fat decomposition	Multiple mechanisms, more significant weight loss effect and better tolerance
Appetite Suppressants	Amphetamines, Rocatlin (banned)	Affects brain neurotransmitters and suppresses appetite	Effective in the short term, but with serious side effects in the long term, some have been banned
Fat absorption inhibitors	Orlistat	Inhibit lipase activity and reduce fat absorption	Does not affect appetite, but can easily cause gastrointestinal discomfort (diarrhea, oily stools)
New compound weight loss drug	Semaglutide ( GLP-1 single agonist), naltrexone - bupropion	Regulate appetite center or metabolism and improve satiety	Partially effective, but less weight loss than telpotide

📌 Key Differences :

Traditional weight loss drugs mostly use a single mechanism (such as suppressing appetite or reducing fat absorption), while tirpotide acts on appetite regulation and fat metabolism at the same time, improving weight loss efficiency .
Traditional appetite suppressants may affect the nervous system , leading to greater risk of addiction or side effects, while GLP-1/GIP drugs have milder side effects by naturally regulating hormone levels .
Fat absorption inhibitors (such as orlistat) do not affect appetite, but they can easily cause gastrointestinal discomfort and have a weaker weight loss effect .

in conclusion :

• The multiple mechanisms of action of tebuconazole make it more effective than traditional weight loss drugs and more suitable for long-term use .

2. Comparison of clinical research data: Which one has a better weight loss effect?

Research	Telportide ( GLP-1/GIP agonist)	Semaglutide ( GLP-1 monoagonist)	Orlistat (fat absorption inhibitor)
SURMOUNT-1 study (tepoxetine)	Average weight loss after 72 weeks: 22.5%	-	-
STEP-1 study (semaglutide)	-	Average weight loss after 68 weeks: 16.9%	-
XENICAL study (orlistat)	-	-	Average weight loss after 1 year : 7-10%

📌 Data analysis :

• Tipol has the strongest weight loss effect , with an average weight loss of 22.5% after 72 weeks, far exceeding semaglutide ( 16.9% ) and orlistat ( 7-10% ).

• Among traditional weight loss drugs, orlistat has a smaller weight loss effect and is only suitable for people who are slightly overweight . It also has obvious side effects (diarrhea, oily stools).

in conclusion :

• If the goal is substantial weight loss ( >20% body weight loss), tebuconazole is significantly superior to conventional weight loss drugs .

• If you just want to control your diet and reduce fat absorption, traditional medicines may be of some help, but the effect is weak .

3. Side effect comparison: Which one is safer?

Side effect category	Telportide ( GLP-1/GIP )	Appetite suppressants (eg, amphetamines)	Fat absorption inhibitors (orlistat)
Nausea and vomiting	Lightweight , adaptable over time	May occur (some drugs)	none
Gastrointestinal discomfort	Mild bloating, constipation, or diarrhea	May affect gastrointestinal function	Diarrhea and oily stools are common
Cardiovascular risk	No significant effect	Some drugs may increase heart rate and blood pressure	none
Addiction risk	none	Some drugs are addictive (such as amphetamines)	none

📌 Side effect analysis :

• The main side effects of tebuconazole are mild gastrointestinal discomfort, which usually gradually improves after 4-8 weeks and is well tolerated .

• Traditional appetite suppressants may affect the nervous system, and some drugs have been banned (e.g., lorcatrine was withdrawn from the market due to cardiovascular risks).

• The main side effect of orlistat is gastrointestinal discomfort, and some patients find it difficult to use it for a long time .

in conclusion :

• Tipoline has milder side effects and is more suitable for long-term use .

• Traditional appetite suppressants have a higher risk, some have been phased out, and long-term use is not recommended .

4. Conclusion: Which method is more effective? Which one is more suitable for you?

crowd	More suitable drugs	Recommended reason
Want to lose a lot of weight ( >20% body weight loss)	Telportide	The strongest weight loss effect so far, with a 22.5% weight loss after 72 weeks
Mildly overweight ( BMI 27-30 )	Orlistat or telpotide	Orlistat is suitable for people with mild overweight, while telopoietin is more effective
Have tried traditional weight loss pills but failed	Telportide	Traditional drugs are mostly short-term, while telopoietin can maintain a more stable weight in the long term
Want to avoid serious side effects	Telportide or orlistat	Appetite suppressants may have neurological side effects, while orlistat mainly affects the gastrointestinal tract
Unwilling to change eating habits	Telportide	No strict diet is required, and weight loss can be achieved by simply reducing appetite with medication

📌 Final Recommendations :  ✔ If you want to lose weight long-term and reduce weight regain, telopoietin is currently the best choice .  ✔ If you just want to reduce fat absorption and can accept the gastrointestinal side effects, orlistat may be suitable for slightly overweight people .  ✔ Appetite suppressants have been largely phased out and are not recommended for long-term use .