Tipoline vs. semaglutide: Why is the “dual agonist” mechanism stronger?
1. Telpotide vs. semaglutide: Both are GLP-1 receptor agonists, what are the differences in their effects?
In the field of weight loss drugs, Semaglutide ( trade name Wegovy/Ozempic ) was once considered one of the most effective GLP-1 receptor agonists, which can reduce appetite, reduce calorie intake, and delay gastric emptying , thereby helping obese and diabetic patients control their weight. However, Tirzepatide ( Mounjaro ), approved by the FDA in 2022 , completely changed this situation.
The core difference lies in the " dual agonist " mechanism of tilpotide - GLP-1 + GIP receptor dual agonist . Compared with semaglutide, a single GLP-1 receptor agonist, tilpotide can further enhance insulin sensitivity and promote fat decomposition on the basis of controlling appetite, thereby bringing a stronger weight loss effect.
2. GLP-1 receptor agonist ( Semaglutide ): main effect
Semaglutide ( Wegovy/Ozempic ) is a GLP-1 receptor agonist that helps with weight loss primarily through the following actions:
✔ Suppress appetite : Acts on the appetite center of the brain, making people feel fuller and reduce calorie intake.
✔ Delays gastric emptying : Food stays in the stomach longer, prolongs the feeling of fullness, and reduces eating frequency.
✔ Promote insulin secretion and lower blood sugar : Reduce glucagon release, help the body metabolize blood sugar better and reduce fat accumulation.
However, the disadvantage of semaglutide is that its direct effect on fat metabolism is weak, and it is prone to a plateau period after weight loss . Some people may experience a rebound after stopping the drug .
3. The “ dual agonist ” mechanism of tepote: How can GLP-1 + GIP be more potent?
In addition to acting on the GLP-1 receptor, tirpotide can also activate the GIP (glucose-dependent insulinotropic polypeptide) receptor , making it more capable of metabolic regulation.
✔ GLP-1 controls appetite + GIP promotes fat metabolism , a two-pronged approach to accelerate weight loss.
✔ It enhances insulin sensitivity , reduces insulin resistance, and makes blood sugar metabolism more stable. It is suitable for people with prediabetes or metabolic abnormalities.
✔ GIP receptor agonism improves energy metabolism and promotes lipolysis more directly , rather than simply relying on reducing food intake.
✔ GIP can also reduce the side effects of gastrointestinal discomfort , so tepoxetine is better tolerated than semaglutide and has relatively milder side effects .
📌 Comparison of key data ( SURMOUNT vs. STEP study):
|
drug |
Highest weight loss effect |
Clinical trials |
Target Group |
|
telpotide ( Mounjaro ) |
22.5% weight loss |
SURMOUNT-1 study ( 2022 ) |
Obesity, prediabetes, type 2 diabetes patients |
|
semaglutide ( Wegovy ) |
16.9% weight loss |
STEP-1 study ( 2021 ) |
Obese and prediabetic patients |
Studies have shown that the weight loss effect of tebuconazole is about 5.6% higher than that of semaglutide , and it is more advantageous for overweight or diabetic patients.
4. Telbutide vs. semaglutide: Which one is better for you?
✅ If you want a stronger weight loss effect and see weight loss faster, choose tirpotide .
✅ If you have a poor tolerance to GLP-1 drugs (such as Wegovy ) and are prone to nausea and vomiting, tebuconazole may be a better choice .
✅ If you mainly want to control blood sugar but are not too demanding on weight loss, semaglutide can also meet your needs .
✅ If you have insulin resistance or prediabetes, the GIP effect of tepoxetine may improve metabolism even more .
📌 Summarize:
🔹 The " dual agonist " mechanism of tipol makes it more effective than semaglutide in weight loss and metabolic improvement.
🔹 It is suitable for people who need more drastic weight loss, those with prediabetes or diabetes, and those who have poor tolerance to GLP-1 .
🔹 Clinical data confirms that while tipol can control appetite, it can also directly promote fat decomposition, making weight loss more efficient and less likely to rebound.
If you are looking for a more effective scientific weight loss solution, telopoietin may be your best choice!
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