Tipoline vs. semaglutide: Which weight loss injection is more effective?
With the development of medical technology, GLP-1 receptor agonists have become breakthrough drugs for obesity management, among which semaglutide has long been considered the strongest weight loss drug. However, the latest GLP-1/GIP dual agonist , telpotide, has shown a stronger weight loss effect than semaglutide in clinical trials , becoming a new favorite in the market.
So, which one is more effective, telpotide or semaglutide? What are the differences in their weight loss effects, side effects, applicable populations, and prices? This article will combine the latest clinical research data to help you choose the weight loss plan that best suits you.
1. Telpotide vs. semaglutide: core differences
📌 Semaglutide : A GLP-1 receptor agonist whose main function is to reduce appetite, delay gastric emptying , and help reduce calorie intake.
📌 Tipoleptide : A GLP-1/GIP dual agonist that, in addition to reducing appetite , can also promote lipolysis, increase insulin sensitivity, and reduce gastrointestinal side effects .
|
Comparison Dimensions |
Telportide |
Semaglutide |
Comparative advantages |
|
Mechanism of action |
GLP-1 + GIP dual agonist |
GLP-1 monoagonist |
Telpotide can additionally promote lipolysis |
|
Weight loss effect ( 72 weeks) |
An average decrease of 22.5% |
Average decrease of 16.9% |
Telportide is stronger |
|
Proportion of people with weight loss ≥ 20% |
57% |
36% |
Telbutide makes it easier to lose weight |
|
Gastrointestinal side effects (nausea, vomiting, diarrhea) |
less |
More |
Telportide is better tolerated |
|
Improved blood sugar levels (lowered HbA1c ) |
-2.37% |
-1.86% |
Tilpotide is stronger and suitable for people with prediabetes |
|
Price (US market) |
$1,000 - $1,200/ month |
$900 - $1,200/ month |
The price is similar, but tebuconazole is more effective |
|
Target Group |
Obesity, stubborn weight management, prediabetes population |
People with obesity and mild metabolic abnormalities |
Telpotide has a wider application |
📌 Conclusion : Telpotide is superior to semaglutide in weight loss effect, metabolic improvement, and tolerability, and is suitable for people who want to lose weight to the greatest extent .
2. Comparison of weight loss effects: Which drug is faster and more effective?
Several clinical trials have compared the weight loss effects of tilpotide and semaglutide , the most important of which are SURMOUNT-1 (tilpotide) and STEP-1 (semaglutide) .
📌 Weight loss after 72 weeks (SURMOUNT-1 vs. STEP-1)
|
Research |
Telportide |
Semaglutide |
|
Weight loss (average) |
22.5% |
16.9% |
|
Proportion of people with weight loss ≥ 20% |
57% |
36% |
|
Maximum weight loss |
27% |
18% |
📌 Key findings :
✔ The average weight loss effect of tebuconazole was 5.6% higher than that of semaglutide , which means that tebuconazole can reduce weight faster in the same period of time .
✔ 57% of patients lost more than 20% of their body weight, significantly more than 36% for semaglutide .
✔ The highest weight loss rate reached 27% , far exceeding the 18% of semaglutide .
💡 Conclusion: Telpotide is the strongest weight loss drug currently approved by the FDA . It has a stronger and faster weight loss effect than semaglutide and is particularly suitable for people who need to lose a lot of weight.
3. Side effect comparison: Which one is better tolerated?
📌 Common side effects include gastrointestinal discomfort (nausea, vomiting, diarrhea), hypoglycemia, dizziness , etc.
|
Side effect category |
Tipocapeptide ( GLP-1/GIP dual agonist) |
Semaglutide ( GLP-1 monoagonist) |
|
nausea |
31% |
44% |
|
Vomit |
18% |
twenty four% |
|
diarrhea |
twenty one% |
30% |
|
constipate |
14% |
17% |
📌 in conclusion :
• The GIP effect of tepoxetine can reduce the common gastrointestinal side effects of GLP-1 drugs and improve patient tolerance .
• Compared with semaglutide, telpotide has lower incidence of nausea, vomiting, and diarrhea and is easier to use long-term .
💡 Final verdict: If you are concerned about gastrointestinal discomfort, tebuconazole is better tolerated and is a better choice for long-term use.
4. Telbutide vs. semaglutide: Which drug is better for you?
📌 If your goal is maximum weight loss ( >20% body weight loss)
✔ Tipol is a stronger option , with a weight loss of up to 27% , far exceeding semaglutide ( 18% ).
📌 If you have had difficulty adhering to GLP-1 medication due to side effects (nausea, vomiting)
✔ The GIP effect of tepoxetine can reduce gastrointestinal side effects, improve tolerance , and make it more suitable for long-term use.
📌 If your main concern is sugar control (such as diabetics)
✔ Both drugs can effectively lower blood sugar , but tebuconazole has a greater blood sugar-lowering effect and is more advantageous for patients with prediabetes.
💡 Final conclusion : If your goal is to lose weight faster and more significantly while minimizing side effects, tebuconazole is currently the best choice.
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