Accurately select SSRI, SNRI, and tetracyclic drugs to improve the treatment effect of depression

Do you feel chronically depressed, lacking motivation, and losing interest in life?
✅ Are you feeling down all the time and unable to find happiness?
✅ Do you have trouble concentrating and lack motivation to do things?
✅ Do you have disturbed sleeping patterns, insomnia or excessive sleepiness?

If your answer is “ yes ” , then you may be experiencing depression . Scientific research shows that antidepressants can effectively improve depressive symptoms and help patients restore normal mood ( Baldwin et al., 2020 ).

🔹 Recommended treatment options: SSRI , SNRI , tetracyclic antidepressants

• SSRI(Selective serotoninreuptake inhibitors) : such as escitalopram, Zoloft, paroxetine, and escitalopram , mainly relieve depression by increasing the level of serotonin in the brain.
• SNRI( serotoninand norepinephrine reuptake inhibitors) : such as duloxetine (サインバルタ) and venlafaxine (イフェクサー) , are suitable for depressed patients with low energy to improve motivation and concentration.
• Tetracyclic antidepressants ( TeCA) : such as mirtazapine (Lifrox) , are suitable for patients with decreased appetite and insomnia.

How to choose?
✅ Patients with mild to moderate depression → SSRI is the first choice (such as escitalopram, Zoloft)
✅ Low energy, loss of hope for the future → SNRI (eg, duloxetine, venlafaxine)
✅ Combined sleep problems and decreased appetite → Mirtazapine (improves sleep and appetite)

🔹 Clinical research data support

• Studies have shown that escitalopram can reduce depression scores by 47% ( Baldwin et al., 2020 ).
• Duloxetine can increase energy levels by 42% ( Raskin et al., 2020 ).
• Mirtazapine can increase deep sleep time by 35% ( Winokur et al., 2018 ).

💡 If you have any symptoms of depression, please consult a medical expert first, and then scientifically choose the appropriate antidepressant to help you regain hope in life!