Average weight loss 22.5%” - The strongest weight loss drug with 72 weeks of clinical evidence is here

1. Clinical research data: weight loss hits a new high

📌 SURMOUNT-1 study (published in NEJM in 2022 ) highlights:

•       Average baseline weight of subjects: 104.8kg

•       Average weight loss after 72 weeks of tepoxetine: 22.5% (approximately 24 kg )

•       57.4% of patients lost ≥20% of their body weight , a significant improvement compared to Wegovy ( 36% )

•       Visceral fat decreased by 32% and waist circumference decreased by 19cm+

Compared with other mainstream weight loss drugs:

Drug Name	Average weight loss	Use cycle
Telportide	22.5%	72 weeks
semaglutide ( Wegovy )	16.9%	68 weeks
Orlistat	5-10%	24-52 weeks
Naltrexone - bupropion ( Contrave )	5-8%	24-56 weeks

📌 Conclusion: Tipoline not only reduces blood pressure quickly but also reduces blood pressure steadily, and is significantly superior to other drugs.

 

2. Why can tepote reduce weight so much? The mechanism is revealed

Tipoline is a GLP-1/GIP dual agonist that jointly regulates two key metabolic hormones in the human body:

hormone	Function	Telpotide action
GLP-1	Suppress appetite and promote insulin secretion	Reduce caloric intake and delay gastric emptying
GIP	Improve fat metabolism efficiency and reduce insulin resistance	Promote fat oxidation and control blood sugar fluctuations

📌 The dual-pathway synergy makes it far superior to GLP-1 single agonists such as Wegovy in terms of fat reduction, sugar control, and food control .

 

3. Who is suitable for using telpotide?

📌 FDA recommended applicable population :

•       Obese people with BMI ≥30

•       BMI ≥27 with diabetes, hyperlipidemia, fatty liver, and metabolic syndrome

📌 In actual use, it is also suitable for:

•       People who have failed to lose weight through dieting

•       Not suitable for those who exercise at high intensity for a long time or control their diet

•       People who want to lose weight and improve metabolic health

 

4. Is it safe? 72 weeks of data give the answer

📌 The main side effects are mild to moderate gastrointestinal discomfort:

•       Nausea, constipation, diarrhea, usually relieved after the first 4 weeks of adjustment

•       No risk of severe hypoglycemia (unless concomitant glucose-lowering drugs are used)

•       Non-addictive, can be used for a long time, and can still partially maintain body weight after stopping the drug

📌 SURMOUNT research shows that the rebound in weight after stopping the medication is much smaller than with traditional weight loss drugs , and some people still maintain a weight loss of more than 15% .

 

5. How do I start using telpotide?

📌 Recommended dose escalation pathway:

•       Weeks 1 to 4 : 2.5 mg (starting dose)

•       Weeks 5 to 8 : 5 mg

•       After that, you can gradually increase the dosage to 10mg or 15mg based on your doctor's advice.

📌 Dietary recommendations:

•       A high-protein, low-refined carbohydrate diet

•       Avoid overeating and reduce high-fat intake in the early stages to reduce side effects

 

Conclusion: Tipoline redefines weight loss drugs

It is not enough to just " suppress appetite " , real weight loss should start from the metabolic mechanism .
Through the dual agonist mechanism of GLP-1+GIP , tepote has created a new weight loss path of " losing more weight, losing more steadily, and losing more healthily " , becoming a long-term solution for people with metabolic obesity .

 

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