Can telopoietin be used for a long time? What are its safety, dependence, and rebound effects after discontinuation of medication?
1. Can tepote be used for a long time?
Tirzepatide ( trade name Mounjaro ) is a GLP-1 + GIP dual receptor agonist that has been approved by the FDA for the management of type 2 diabetes and obesity . A large number of clinical studies have shown that tirzepatide is not only effective in weight loss and improving metabolism, but is also suitable for long-term use , and its tolerability is better than traditional GLP-1 receptor agonists (such as semaglutide Wegovy ).
📌 Safety evidence for long-term use:
• SURMOUNT-1 study ( 72 weeks): Tipoline was safely used for more than 1.5 years with no serious adverse reactions observed.
• SURPASS-2 study ( 40 weeks): Compared with semaglutide, tepoxetine is more stable in terms of glucose control and weight loss , and there is no long-term decrease in tolerance.
• FDA approved for long-term use : Currently , tirpotide has been approved for long-term weight management and is suitable for patients with obesity and overweight with metabolic diseases.
Therefore, for people who need to continuously control their weight, tebuconazole can be used for a long time and is relatively safe.
2. Will tepote cause dependence?
Many people worry whether the use of weight-loss drugs will lead to dependence and whether the effects will rebound after stopping the drugs.
✅ Tipoline is not an addictive drug . Unlike traditional stimulant appetite suppressants (such as phentermine ), it does not directly act on the central nervous system and does not cause psychological dependence .
✅ The mechanism of action is to regulate physiological metabolism , helping the body to naturally reduce appetite and improve insulin sensitivity , which is completely different from addictive substances such as caffeine and nicotine.
✅ There is no withdrawal reaction . If long-term users want to stop taking the drug, they can gradually reduce the dosage to allow the body to adapt and avoid metabolic fluctuations caused by sudden discontinuation of the drug.
💡 However, it should be noted that the effect of telopoietin depends on its continued use . Once the drug is stopped, the body's appetite control and metabolic regulation may gradually return to their original state. Therefore, reasonable management of diet and exercise is still the key to maintaining long-term weight loss effects .
3. Will there be a rebound after stopping the medication? How to avoid it?
Weight changes after stopping medication depend on the individual's lifestyle habits and the body's metabolic adaptability .
📌 Clinical research data:
• SURMOUNT-4 study ( 2023 ):
• After 36 weeks of continuous use, the average weight loss was 20.9% .
• But one year after stopping the medication, some people regained about 6% of their weight , but were still 14% lower than their starting weight.
• Studies have shown that if diet and exercise are not adjusted after stopping the drug, some weight may be regained .
📌 How to avoid rebound after stopping medication?
✔ Reduce the dosage gradually, don't stop the medication suddenly : Doctors usually recommend reducing the dosage gradually to allow the body to adapt slowly.
✔ Establish healthy eating habits : increase protein intake and reduce high-sugar, high-carb foods to maintain stable blood sugar.
✔ Maintain moderate exercise : 3 to 5 times of aerobic exercise per week, combined with strength training, will help maintain muscle mass and metabolic rate.
✔ Monitor weight changes : If you notice a rapid regain of weight, consider reassessing the need to continue medication or adjust your lifestyle.
💡
• Tipoline can be used for a long time, and its long-term safety has been approved by the FDA .
• It will not cause psychological dependence or withdrawal symptoms .
• If you do not change your eating and exercise habits after stopping the medication, some weight may be regained , but it will be easier to maintain than with traditional weight loss methods.
• Reasonable adjustments to your lifestyle can help maintain weight loss results in the long term and reduce the risk of rebound.
📌 For people who want to control their weight in the long term, telopoietin is a safe and sustainable solution, but it still needs to be combined with a healthy lifestyle to achieve the best results!
