Diabetics don't have to worry about losing weight, Trelagliptin succinate tablets can help
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When diabetes meets obesity, how to solve the double challenge
For patients with type 2 diabetes, obesity and blood sugar control are often two major problems. Studies have shown that more than 80% of patients with type 2 diabetes are overweight or obese , and weight loss can not only improve insulin resistance, but also reduce the risk of cardiovascular disease. However, many traditional hypoglycemic drugs (such as insulin and sulfonylureas) may cause weight gain, putting diabetics in a dilemma of "getting fatter the more they are treated."
The good news is that Trelagliptin Succinate , as a long-acting DPP-4 inhibitor , can not only control blood sugar steadily , but also prevent weight gain and may even indirectly assist in weight loss, becoming a "golden partner" for the health management of diabetics.
This article will analyze in depth:
✅ Why is it more difficult for obese diabetics to lose weight?
✅ How does Trelagliptin help control both blood sugar and weight?
✅ What kind of lifestyle can double the weight loss effect?
1. Why is it more difficult for diabetics to lose weight than ordinary people?
(1) Insulin resistance: the starting point of a vicious cycle
Obesity can cause abnormal enlargement of fat cells , release a large amount of free fatty acids and inflammatory factors, interfere with insulin signal transduction, and form "insulin resistance". Insulin resistance will make the body more inclined to store fat , forming a vicious cycle of "the fatter → the higher the blood sugar → the harder it is to lose weight".
(2) The “weight gain side effect” of traditional hypoglycemic drugs
● Insulin : Promotes the conversion of glucose into fat, which may lead to weight gain of 1-4kg/year.
● Sulfonylureas (such as glimepiride) : stimulate insulin secretion and also have the risk of weight gain.
● Thiazolidinediones (such as pioglitazone) : may cause water and sodium retention and fat accumulation.
(3) Psychological stress: the double whammy of anxiety and hunger
Long-term dietary restrictions to control sugar can easily trigger emotional eating , and high blood sugar itself interferes with the function of leptin (a hormone that suppresses appetite), making it more difficult for people to resist the temptation of high-calorie foods.
2. Trelagliptin succinate tablets: a "smart choice" to control sugar without gaining weight
(1) Unique mechanism: precise regulation without stimulating fat synthesis
Trelagliptin inhibits DPP-4 enzyme and increases GLP-1 (glucagon-like peptide-1) levels to achieve "intelligent blood sugar reduction":
● After meal : Promote insulin secretion and lower blood sugar.
● Fasting : inhibits glucagon and reduces liver glucose output.
Key advantage : Does not directly stimulate excessive insulin secretion, avoiding hypoglycemia and fat accumulation.
(2) Clinical evidence: weight neutrality or even potential weight loss
● Japanese study : After 52 weeks of treatment with trelagliptin alone, the average weight change of patients was close to ±0kg (compared to 1.5-3kg weight gain with sulfonylureas).
● Combination therapy : When used in combination with metformin (a weight-loss drug), some patients experience mild weight loss (1-2 kg).
(3) Take medication once a week to reduce the risk of “revenge eating”
Traditional hypoglycemic drugs need to be taken multiple times a day, which may cause patients to feel psychological pressure of being "bound by the disease". However, the weekly administration of trelagliptin can not only stabilize blood sugar control, but also reduce medication anxiety, and indirectly help maintain a healthy eating mentality.
3. Trelagliptin + lifestyle adjustment: a strategy to double your weight loss effect
(1) Dietary recommendations: low GI + high protein combination
● Breakfast : eggs + oatmeal + green leafy vegetables (delay glucose absorption).
● Lunch/dinner : brown rice + chicken breast + broccoli (avoid refined carbohydrates that can cause a sudden increase in blood sugar).
● Snack : unsweetened yogurt or nuts (to suppress hunger).
(2) Exercise plan: aerobic + resistance exercise
● Aerobic exercise : brisk walking, swimming (150 minutes per week to burn visceral fat).
● Resistance training : dumbbells, elastic bands (increase muscle mass and improve basal metabolism).
(3) Sleep and stress management
● Ensure 7-8 hours of sleep (lack of sleep will increase cortisol and promote abdominal fat accumulation).
● Try mindfulness meditation (reduces emotional eating).
4. FAQ
Q1: Can trelagliptin help lose weight directly?
A: It is not a weight loss drug itself, but it creates favorable conditions for weight loss by preventing weight gain and improving metabolism.
Q2: Who is suitable for using trelagliptin to assist in weight loss?
A: Patients with type 2 diabetes and a BMI ≥ 24, especially those who are taking insulin or sulfonylureas and have significant weight gain.
Q3: Do I need to take other medicines?
A: It can be used in combination with metformin (for weight loss) or SGLT-2 inhibitors (for sugar elimination and weight loss), but it requires doctor’s evaluation.
5. Control sugar intake scientifically and lose weight healthily
Obesity and diabetes are like a pair of "twin brothers", but trelagliptin succinate tablets provide a sugar control solution without gaining weight . Combined with a correct lifestyle, it is entirely possible to break the curse of "the more you treat, the fatter you get."
Remember : Losing 5%-10% of your weight can significantly improve insulin sensitivity! If you are struggling with both blood sugar and weight, consult your doctor and let Trelagliptin help you achieve your health goals.
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⚠️ Warm reminder: This article is for reference only, specific medication should be taken according to the doctor's advice.
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