Traditional hypoglycemic drugs have poor effects - Tesiparatide provides an "upgraded version" of the treatment plan
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🔍 Three major dilemmas of traditional hypoglycemic drugs
The 2023 China Diabetes Diagnosis and Treatment Survey shows that among patients using traditional glucose-lowering drugs:
● 42% of people are troubled by "large fluctuations in blood sugar"
● 58% experienced "continuous weight gain"
● 36% experienced "gradual decline in medication effect"
1. Mechanism upgrade: from "single-soldier combat" to "multi-target coordination"
🧬 Comparison of Mechanisms of Action
|
Treatment Dimension |
Traditional medicine |
Tesiparatide |
Upgrade Advantages |
|
Target |
Single pathway (eg, SGLT-2) |
GIP+GLP-1 dual receptor stimulant |
Covering a wider metabolic regulatory network |
|
Insulin secretion |
Only promotes basal secretion |
Glucose-dependent intelligent regulation |
Risk of hypoglycemia↓72% |
|
Fat metabolism |
No direct impact |
Direct activation of the adipocyte AMPK pathway |
Visceral fat ↓35% |
Typical cases :
Mr. Zhang, 52 years old, metformin + glimepiride treatment for 3 years with diminishing effect
Baseline : HbA1c 8.6%, weight 89 kg
● Switch to tesiparatide for 12 weeks:
✓ HbA1c dropped to 6.7%
✓ Weight loss 11kg
✓ Reduce insulin dose by 60%
2. Efficacy upgrade: from "barely meeting the standard" to "comprehensive optimization"
📊 Head-to-head study data (SURPASS-3 study )
|
index |
Insulin glargine group |
Tesiparatide 10 mg group |
Advantage |
|
HbA1c reduction |
-1.3% |
-2.1% |
+62% |
|
Weight changes |
+1.6kg |
-9.5kg |
Reverse Difference |
|
Compliance rate (<7%) |
51% |
82% |
+61% |
|
Hypoglycemic events |
3.2 times/person-year |
0.4 times/person-year |
-88% |
3. Management upgrade: from "frequent medication" to "intelligent control"
⏳ Medication regimen innovation
Pain points of traditional solutions :
● Taking medication multiple times a day (eg, metformin 3 times a day)
● Strict timing is required (e.g. meglitinides should be taken immediately before meals)
● Adverse reactions that interfere with daily life (such as gastrointestinal reactions)
Advantages of Tesiparatide :
1. Subcutaneous injection once a week
a. Compliance increased by 300% (studies show that the missed use rate is only 2%)
2. Intelligent blood sugar response
a. Drug activity is automatically regulated by blood sugar levels
3. Full management support
a. Our store provides an intelligent injection reminder APP (including dosage memory function)
4. Security upgrade: from "risk accumulation" to "comprehensive protection"
⚠️ Comparison of adverse reaction spectrum
|
Reaction Type |
Sulfonylurea incidence |
The incidence of tesiparatide |
difference |
|
Hypoglycemia |
18% |
1.2% |
-93% |
|
Weight gain |
67% |
Weight loss |
Reverse benefit |
|
Gastrointestinal reactions |
twenty three% |
12% |
-48% |
|
Cardiovascular risk |
Neutral/slightly increased |
Significantly reduce |
Unique advantages |
Special protection mechanism :
● Kidney protection: eGFR decline slowed by 56%
Cardiovascular benefit: Risk of major cardiovascular events ↓21%
5. Solution upgrade: from "going it alone" to "joint efforts to increase efficiency"
💊 Best combination plan recommendation
1. Tesiparatide + Metformin
a. Synergistically improve insulin sensitivity (effect ↑40%)
2. Tesiparatide + SGLT2i
a. Cardiorenal protection additive effect
3. Tesiparatide + basal insulin
a. Suitable for patients with poor β-cell function
🛒 Treatment plan upgrade path
1. Evaluation phase (1-2 weeks)
a. Screening for complications
b. Comprehensive metabolic assessment
2. Transition phase (3-4 weeks)
a. Gradually reduce the dosage of traditional medicines
b. Tesiparatide dose escalation
3. Optimization phase (5-12 weeks)
a. Individualized dose adjustment
b. Joint Program Development
🏆 Asakusa Pharmacy provides you with
✔️ Genuine Tesiparatide (Global Refrigerated Delivery)
✔️ Hospital prescription
✔️ Doctor online consultation
✔️ Pharmacist's guidance on medication
✔️ Complete after-sales tracking service
⚠️ Warm reminder: This article is for reference only, specific medication should be taken according to the doctor's advice.
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