Say goodbye to the fear of sleeping pills! Why are Suvorexant, Lebrexant, and Dalebrexant not addictive?
1.Why are many people afraid of taking sleeping pills?
Long-term insomnia can have a serious impact on physical health, mental state and quality of life , so many insomnia patients will seek medication. However, some people are afraid of sleeping pills . They worry about:
❌ After taking sleeping pills, you can't stop?
❌ Will long-term use lead to brain degeneration and memory loss?
❌ Feeling low in spirits during the day, affecting your work and life?
❌ Insomnia becomes more severe after stopping medication, do I have to continue to rely on it?
These concerns are not groundless, because traditional sleeping pills (such as diazepam, alprazolam, and zopiclone) are indeed prone to dependence and tolerance , and long-term use may cause withdrawal symptoms, cognitive impairment, and daytime fatigue ( Lader, 2011 ). However, the new generation of sleeping pills (suvorexant, lebrexant, and darilexant) avoid these problems through a new mechanism of action , making long-term sleep aids safer.
📌 Core question: Why are the new generation of sleeping pills not addictive?
✅ The mechanisms of action are different — they don’t calm the brain directly, but instead reduce wakefulness signals and help the body fall asleep naturally. ✅ Does not affect deep sleep - traditional sleeping pills may weaken REM sleep, while new sleeping pills do not disrupt normal sleep structure .
✅ Non-dependence — no tolerance is formed after long-term use, and sleep remains stable after discontinuation of the drug ( Sun et al., 2021 ).
So how do these three new sleeping pills work? And why are they safer than traditional sleeping pills?
2.Why are traditional sleeping pills addictive?
In the past, doctors often prescribed benzodiazepines (such as diazepam, alprazolam) or non-benzodiazepines (such as zopiclone, zolpidem) to treat insomnia. Their main mechanism of action is to enhance the inhibitory effect of GABA ( gamma- aminobutyric acid) receptors , thereby forcibly calming the brain and making people fall asleep quickly .
📌 Problems with traditional sleeping pills :
❌ The brain needs higher doses after it adapts - after long-term use, the brain develops tolerance to the drug and requires increased doses to maintain the sleep-aiding effect.
❌ Rebound insomnia after stopping the medication - suddenly stopping the medication may cause the brain's arousal system to become overactive, leading to more severe insomnia.
❌ Impact on memory and cognitive abilities – Long-term use can interfere with the brain’s neural connections and increase the risk of Alzheimer’s disease ( Billioti de Gage et al., 2014 ).
❌ Morning drowsiness and daytime sleepiness - Due to the residual effects of the medication, many people still feel drowsy in the morning, affecting their daily life ( Kuriyama & Endo, 2018 ).
These problems prompted scientists to look for safer, non-addictive sleep aids. As a result, orexin receptor antagonists (such as suvorexant, lebrexant, and darilexant) came into being , completely changing the landscape of sleep aids.
3.Why are the new generation of sleeping pills not addictive?
Orexin is a neurotransmitter secreted by the brain's hypothalamus that is responsible for maintaining a state of wakefulness . When orexin levels are high, the brain remains awake, making it difficult to fall asleep .
Suvorexant, Lebrexant, and Darifurexant are drugs called orexin receptor antagonists (ORAs ) , which work by reducing arousal signals rather than forcibly sedating the brain .
📌 Why doesn't this mechanism lead to addiction?
✅ It does not directly stimulate the GABA system and will not cause dependence or withdrawal symptoms.
✅ It only acts on the orexin receptors, does not affect deep sleep , and makes the sleep structure more natural.
✅ Long-term use will not cause tolerance , and sleep remains stable after discontinuation of the drug ( Sun et al., 2021 ).
✅ It does not affect the daytime mental state . After taking the medicine, you will still be awake in the morning and will not feel tired ( Herring et al., 2016 ).
Research data support
• After 12 months of long-term use of suvorexant, there was no significant decrease in sleep quality and no withdrawal symptoms after discontinuation of the drug ( Sun et al., 2021 ).
• Clinical trials of Lebrexant showed that there was no tolerance after 6 months of continuous use, and sleep remained stable after discontinuation of the drug ( Ueno et al., 2022 ).
• Dauvilliers can increase the proportion of deep sleep without affecting daytime wakefulness ( Dauvilliers et al., 2022 ).
4. How to choose the sleeping pill that’s best for you?
|
Types of Insomnia |
Suitable sleeping pills |
Mechanism of action |
|
Difficulty falling asleep |
Lemborexant |
Reduce wakefulness signals and speed up falling asleep |
|
Waking up easily in the middle of the night |
Suvorexant |
Maintain stable sleep throughout the night and reduce nighttime awakenings |
|
Light sleep, tiredness in the morning |
Daridorexant |
Improve the proportion of deep sleep and make you more energetic in the morning |
📌 Correct use :
💊 Lebrexan ( 5-10mg ) - Suitable for people who have difficulty falling asleep, take 30 minutes before bedtime.
💊 Suvorexant ( 10-20mg ) - Suitable for those who wake up easily at night, ensuring at least 7 hours of sleep.
💊 Dali Lexan ( 25mg ) - suitable for people who feel tired in the morning, to improve the quality of deep sleep.
💡 Note :
✅ After taking the medicine, you need to ensure at least 7 hours of sleep to avoid fatigue the next day.
✅ Avoid using it with alcohol or caffeine as they may affect the efficacy of the drug.
✅ Maintain a regular schedule, reduce the use of electronic devices, and improve the sleep-aiding effect .
🛒Leborexant 2.5mg 100 tablets / box
🛒Leborexant 5mg 100 tablets / box
🛒Leborexant 10mg 100 tablets / box
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