Niu Che Shen Qi Wan 2.5g (107) 42 packs (14 days) Tsumura Niu Che Shen Qi Wan Ekis granules Tsumura Kampo

Niu Che Shen Qi Pills extract granules are derived from a classic prescription and contain Chinese medicinal extracts such as Rehmannia glutinosa and Cornus officinalis. They have the effects of warming and tonifying the kidney yang, transforming qi and promoting water circulation. They are suitable for symptoms such as soreness of the waist and knees, chills and cold limbs, edema, and difficulty urinating caused by insufficient kidney yang.

1. Basic information of the drug

1. Generic name : Niu Che Shen Qi Wan extract granules (Chinese medicine preparation)
2. English name : No clear record
3. Product name : Tsumura Niu Che Shen Qi Wan Extract Granules (Medical Use)
4. Dosage form : Granules
5. Indications : Used for the following symptoms of easy fatigue, cold limbs, abnormal urine volume (reduced or polyuria) accompanied by thirst: lower limb pain, back pain, numbness, blurred vision in the elderly, itching, difficulty urinating, frequent urination, and edema.
6. Element :
   • Active ingredients: Each 7.5g contains 4.5g of the dry extract of the following mixed herbs (5.0g of Rehmannia root, 3.0g of Chinese yam, 3.0g of Achyranthes bidentata, 3.0g of Poria cocos, 3.0g of Cornus officinalis, 3.0g of Paeonia suffruticosa, 3.0g of Alisma orientalis, 1.0g of Cinnamon bark, 3.0g of Plantago seed, 1.0g of Aconite powder).
   • Additives: magnesium stearate, lactose hydrate, sucrose fatty acid esters.
7. Properties : Gray-brown granules with a peculiar odor, slightly sweet and sour. Identification code: Tsumura/107.

2. Usage and Dosage

3. Taboo

IV. Precautions

1. Special Populations :
   • Pregnant women or women who may become pregnant: It is recommended not to use (containing Achyranthes bidentata and Paeonia suffruticosa may increase the risk of miscarriage, and Aconite powder may easily cause side effects).
   • Lactating women: We need to weigh the benefits of treatment against the nutrition of breast milk and consider whether to continue breastfeeding.
   • Children: Use with caution (including aconite powder).
   • Elderly people: It is recommended to reduce the dosage (physiological functions are usually reduced).
   • People with weak gastrointestinal tract, heat intolerance and blushing face, or excessive physical strength are more likely to experience adverse reactions (such as palpitations, nausea, gastrointestinal discomfort, etc.), so be cautious.
2. Medication Instructions :
   • The medication should be used in combination with the patient's physical condition (symptoms, signs), and continued use should be avoided if symptoms do not improve.
   • When used in combination with other Kampo preparations, pay attention to the duplication of crude drug ingredients, and especially avoid using it in combination with preparations containing aconite.
3. Drug storage :
   • Store at room temperature away from direct sunlight and moisture.
   • After opening, please keep away from moisture.
   • Validity period: 3 years.

5. Adverse Reactions

1. Allergic reaction : The frequency is unknown, rash, redness, itching, etc. may occur.
2. Digestive system reactions : The frequency is unknown, but symptoms may include loss of appetite, stomach discomfort, nausea, vomiting, abdominal distension, abdominal pain, diarrhea, and constipation.
3. Other serious adverse reactions :
   • Interstitial pneumonia (frequency unknown): Symptoms include cough, dyspnea, fever, etc., and the drug should be stopped immediately and examined and treated.
   • Liver dysfunction, jaundice (frequency unknown): Significant elevation of liver enzymes such as AST and ALT may occur.
   • Others: palpitations, dizziness, tongue numbness, etc. (frequency unknown).

6. Drug Interactions

7. Pharmacological Action

1. Analgesic effect : Inhibits pain signal transmission by affecting opioid receptors, NO synthesis, etc.
2. Blood flow improvement effect : Increase peripheral blood flow (such as forearm skin blood flow, peroneal muscle blood flow), and improve blood circulation.
3. Improve frequent urination : inhibit overactive bladder, reduce the frequency of bladder contractions, and is related to neurotransmitter regulation.
4. Neuroprotective effect : Inhibits the decrease in sciatic nerve conduction velocity in diabetic model animals and improves hyperalgesia.

8. Pharmacokinetics

IX. Clinical Research

• After taking 2.5g orally, diabetic patients experienced increased forearm skin blood flow and increased palm temperature within 90 to 120 minutes.
• Animal experiments have shown that it can inhibit overactive bladder, improve nerve conduction function and abnormal pain sensation.

10. Packaging specifications

• 500g / bottle
• 5kg (500g×10)/box
• 2.5g×42 pack/pack
• 2.5g×189 pack/pack

11. Production Information

Manufacturer : Tsumura Co., Ltd.