"Will taking medicine make you dull?" You need sleep, not sedation

1. The truth about becoming dull : sedation ≠ sleep

Most of the traditional sleeping pills represented by diazepam, estazolam, and zopiclone belong to:

•       Benzodiazepines

•       Nonbenzodiazepines (eg, zolpidem)

Its mechanism is:

•       Strongly activates GABA-A receptors and inhibits widespread activity of the nervous system

•       Forcefully suppressing the brain and creating a " false sense of sleep " has a great impact on sleep structure

📌 turn out:

•       Falling asleep quickly, but deep sleep ( N3 ) and rapid eye movement ( REM ) are impaired

•       Poor concentration, low mood, and slow cognitive response after waking up

•       Long-term use may increase the risk of cognitive decline ( Billioti de Gage et al., 2014 )

 

2. ORAs : Let the awake nerves “ calm themselves down ”

ORAs ( Orexin Receptor Antagonists ) drugs such as Suvorexant, Lebrexant, and Darilexant have completely different mechanisms:

•       Inhibits the orexin system, a neurotransmitter in the brain that helps maintain wakefulness

•       It’s not about “ turning off the whole brain ” , but precisely turning off the arousal circuit

•       Does not affect GABA , does not impair cognitive function or emotional balance

•       The sleep structure is more natural, preserving the N3 and REM phases and promoting true restorative sleep

📌 In a word: ORAs are about " persuading people to wake up " , not " knocking people's brains " .

 

3. What does scientific research say? Will it become dull? There is data to prove it.

✅ Impact on cognitive function: No significant changes

•       Muehlan et al., 2022 : After taking Dalire for a long time, cognitive test performance was no different from the placebo group, and reaction time and memory were stable

✅ Morning state: more alert the next day

•       Sun et al., 2021 : Suvorexan users showed no significant difference from the non-drug group in simulated driving and language logic tasks, and had no hangover

✅ Sleep Quality vs. Daytime Performance

•       Users of ORAs not only sleep better at night, but also feel less sleepy during the day and have better concentration ( Ueno et al., 2022 )

 

4. Who particularly needs “ awake sleeping pills ” ?

•       Office workers, drivers, and those who get up early to take care of their families should not experience " drug inertia "

•       Students during exam period, knowledge workers, creative industry people, rely on cognitive performance

•       People who have given up on traditional medicines because they caused them to feel " drowsy "

•       Insomnia patients who want to improve their sleep quality in the long term without affecting their living conditions

 

Conclusion: A good sleep aid is not about sleeping soundly, but about waking up well

You are worried that taking medicine will make you " dull " because the medicine you have been exposed to may be the last generation of medicine. The new generation of ORAs allows you to fall asleep in a natural rhythm and wake up after your body recovers . It does not damage your cognition or memory, and does not affect your expression and thinking. A truly good sleep is achieved without sacrificing the brain's wakefulness .

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