"Always worried that the drug's effect will weaken and I'll take more and more"? Research shows that these drugs will not cause tolerance even if taken for a long time

1. First clarify " tolerance " and " addiction " : they are not the same thing

•       Tolerance : refers to the fact that the efficacy of the same dose of drug gradually decreases over time, and the dose needs to be increased to maintain the effect.

•       Addiction : includes physical dependence (withdrawal reaction) and psychological dependence (inability to live without the sense of security brought by drugs) .

📌 Many traditional sleeping pills (such as benzodiazepines) have both of these problems :

•       After taking it for a long time, the effect is getting worse and worse

•       When you want to stop, you will suffer from insomnia and irritability.

•       Eventually, they fall into a vicious cycle of " taking higher and higher doses + collapsing when stopping the medication "

This is the reason why many people would rather suffer from insomnia than take medicine .

 

2. ORAs: Scientific mechanisms determine that they will not produce tolerance

Orexin receptor antagonists ( ORAs ) , represented by suvorexant, leborexant, and darilexant , have a mechanism of action that determines that they will not have the tolerance problems of traditional drugs:

Comparison of modes of action	GABA -based traditional medicines	ORAs
Target receptor	Directly calms GABA neural pathways	Inhibits orexin (arousal) neural pathways
Does it interfere with the brain's sleep system?	Forced Intervention	Homeopathic assistance
Does it disrupt sleep structure?	Yes (suppresses deep sleep)	No (retain N3 and REM )
Is it easy to tolerate?	✅ yes	❌ no
Is it necessary to increase the dosage for long-term use?	✅ need	❌ unnecessary

📌 ORAs do not make you " fall asleep " , but restore your " ability to fall asleep " . Unlike the GABA system, which constantly " bombs " the brain, they do not cause the body to have a " sense of resistance " or " need for upgrades " .

 

3. Empirical study: ORAs have stable efficacy after long-term use and do not require additional dosage

🔬 Suvorex

•       A 12 -month long-term study showed that continuous use of suovoluine can steadily improve sleep maintenance time and quality without the need for dose escalation ( Sun et al., 2021 ).

•       There is no rebound insomnia or withdrawal symptoms after stopping the drug, and the brain has learned to fall asleep independently.

🔬 Leibersson

•       In a 6 -month randomized, double-blind study, patients in all dose groups showed stable improvements in sleep onset time and number of awakenings, with no development of tolerance ( Ueno et al., 2022 ).

•       Even if the medication is stopped, the sleep rhythm remains good and there is no need to transition back to the medication .

🔬 Dale Raisin

•       Clinical data show that even when used for a long time in elderly people over 60 years old, the efficacy of the drug remains stable and there is no need to increase the dosage ( Muehlan et al., 2021 ).

•       At the same time, deep sleep structure (stage N3 ) is preserved, which is extremely meaningful for restorative sleep.

 

4. You don’t have to “ eat more and more ” to “ sleep better and better ”

The correct idea of ​​using ORAs is:

•       ✅ Use during periods of rhythm disturbance to help the nervous system " restart "

•       ✅ It is advisable to use it for 1 to 3 weeks, and you can also maintain long-term rhythm regulation under the advice of a doctor

•       ✅ There is no need to reduce the dosage when stopping the drug, and there will be no uncontrolled insomnia

You don't need to take " permanent medication " or increase the dosage to " squeeze out sleepiness " . What you need is a tool that helps you restore your sleep rhythm rather than taking control of your sleep .

 

Conclusion: Control is not about giving up medication, but choosing medication that will not control you

In fact, what insomniacs fear most is not insomnia itself, but " Am I losing control of my life ?" ORAs provide another answer: scientific control, stable efficacy, and phased withdrawal . No more worrying about " taking more and more " or " not being able to stop " . You have the right to use it when you need it, and go back to sleep lightly after recovery. Sleep aids do not mean giving up autonomy. The right choice of drugs is your re-control of your own rhythm. 

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