Who is telopoietin suitable for? - Can this drug be used for your type of obesity?
Obesity not only affects appearance, but is also a chronic metabolic disease that is closely related to the risks of type 2 diabetes, hypertension, fatty liver, cardiovascular disease, etc. However, different types of obesity require different weight loss strategies , and traditional dieting, exercise, and even some weight loss drugs may not be effective for some people.
In recent years, GLP-1 receptor agonists have become the core drugs for obesity management . Among them , telopoietin is considered to be the strongest FDA- approved weight loss drug due to its dual agonist mechanism of GLP-1 + GIP . But telopoietin is not suitable for everyone , so who is the most suitable person to use this drug? Who is not suitable? This article will analyze in detail the applicable population, contraindications and medication recommendations for different types of obesity of telopoietin to help you make a scientific choice.
1. Who is tepoxetine suitable for?
📌 FDA -approved applicable population
✔ Adults with BMI ≥30 (obesity) : Applicable to all obese patients, regardless of whether they have metabolic diseases.
✔ Adults with a BMI ≥27 and at least one weight-related disease (such as type 2 diabetes, hypertension, high cholesterol, obstructive sleep apnea, etc.).
✔ For people who want to lose more than 15%-20% of their body weight , clinical studies have shown that tirpotide can reduce an average of 22.5% of body weight in 72 weeks .
📌 Applicable conditions for different obesity types
|
Types of obesity |
Is telpotide suitable? |
Recommended reason |
|
Metabolic obesity (prediabetes, insulin resistance) |
✅ Suitable |
Tipoleptide improves insulin sensitivity, lowers blood sugar, and prevents type 2 diabetes |
|
Stubborn obesity (long-term dieting + exercise are ineffective) |
✅ Suitable |
Traditional methods may not work. Telportide can reduce appetite and improve metabolism through hormone regulation. |
|
Binge-eating obesity (uncontrolled appetite) |
✅ Suitable |
Tipolactide acts on the appetite center in the hypothalamus to help control appetite |
|
Visceral obesity (fat accumulation in the abdomen) |
✅ Suitable |
Study shows that tepoxetine is effective in reducing abdominal fat |
|
Age-related obesity (menopausal / elderly population) |
✅ Suitable |
Can improve weight gain caused by decreased metabolic rate, but individual tolerance needs to be assessed |
|
Mildly overweight ( BMI 25-27 , no other diseases) |
❌ Not recommended |
The FDA indications do not cover this condition. People without serious health risks can try lifestyle interventions first. |
💡 Conclusion: Telpotide is suitable for most obese or metabolically abnormal people, especially for patients who are unable to lose weight for a long time, but it is not recommended for those who are mildly overweight.
2. Who is not suitable for tebucondyl? (Contraindicated groups)
Although telportin is safer and has better tolerability than traditional GLP-1 drugs , there are still some people who are not suitable for it , mainly including the following categories:
📌 1. Patients with thyroid-related diseases
• People with medullary thyroid cancer ( MTC ) or family history of MTC❌ Disable
• Patients with multiple endocrine neoplasia type 2 ( MEN 2 ) ❌ Disable
• People with thyroid nodules or abnormal thyroid function⚠ Doctor's evaluation required
📌 Reason : In animal experiments, tirpotide was found to increase the risk of thyroid C- cell hyperplasia , but this has not been confirmed in human studies. Therefore, it is contraindicated in patients with MTC and MEN 2 .
📌 2. Pregnant women, breastfeeding women, women preparing for pregnancy
• Pregnant women or those planning to become pregnant❌ Disable
• Breastfeeding women ⚠ Doctor's evaluation required
📌 Reason : GLP-1 drugs may affect fetal growth, and it is recommended to stop taking them at least 2 months before planning pregnancy .
📌 3. Patients with gastrointestinal diseases
• Patients with gastroparesis and gastric emptying disorder❌ Disable
• Patients with chronic gastritis, gastric ulcer, irritable bowel syndrome⚠ Doctor's evaluation required
📌 Reason : Tepoxetine delays gastric emptying and may aggravate gastrointestinal diseases.
📌 4. People at high risk of hypoglycemia
• Diabetic patients taking insulin or sulfonylurea hypoglycemic drugs⚠ Dosage adjustment required
📌 Reason : The risk of hypoglycemia is low for tebuconazole itself, but if used in combination with insulin or hypoglycemic drugs, the incidence of hypoglycemia may increase , and blood sugar levels need to be closely monitored.
📌 5. Other special groups
• Severe liver and kidney damage❌ Disable
• Youth under 18 years old ❌ Prohibited (not approved by FDA )
📌 Reason : The safety of tebuconazole has not been established in adolescents and patients with severe hepatic and renal impairment, and its use is not recommended .
💡 Conclusion: If there is a history of thyroid cancer, severe gastrointestinal disease, pregnancy, or severe liver and kidney damage, other weight loss options are recommended.
3. Is telopoietin suitable for you? How to scientifically evaluate it?
📌 Telbutaline may be a good option for you if you:
✅ BMI ≥30 or BMI ≥27 with metabolic problems (diabetes, hypertension, fatty liver, etc.)
✅ Tried dieting, exercise, and traditional medicine many times but still couldn't lose weight
✅ Have a habit of overeating and want to control appetite
✅ Visceral fat accumulation (abdominal obesity)
✅ Want to achieve long-term and stable weight loss results
📌 You should not use tepote if you:
❌ A history of medullary thyroid cancer ( MTC ) or MEN 2
❌ Pregnant women and women planning to have a baby
❌ Patients with gastroparesis and severe gastrointestinal diseases
❌ Severe liver and kidney damage
❌ Under 18 years old
💡 Final conclusion: Telpotide is suitable for most obese people who have difficulty losing weight, but not for pregnant women, people with a history of thyroid cancer, patients with severe gastrointestinal diseases, etc. Scientifically assess your own condition and choose the most appropriate weight loss plan.
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Eli Lilly's official website introduces telportipeptide ( EN )
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