Tandospirone citrate & low-dose sulpiride: safe treatment options for anxiety disorders

Anxiety disorder: When the brain can't stop, life becomes uncontrollable

Have you ever had such an experience?

✅ Are you always worrying for no reason and can't help imagining the worst-case scenario even when things are going well?

✅ Do you feel anxious and stressed every day, and even simple social interactions make you nervous?

✅ Do you have trouble concentrating at work and easily become anxious over trivial matters?

✅ Do you lie in bed at night with your mind full of anxious thoughts and unable to fall asleep?

If these situations have lasted for weeks or even months and have affected your life, work, and relationships, you may be experiencing generalized anxiety disorder ( GAD ) or social anxiety disorder . Studies have shown that approximately 3-7% of people worldwide suffer from anxiety disorders, and more than 60% of these patients fail to receive effective treatment ( Stein et al., 2019 ).

 

Why do anxiety disorders require specific medications?

The core problem of anxiety disorder is " hypervigilance " of the brain.
The brains of people with anxiety disorders often overactivate the sympathetic nervous system , leading to an imbalance in neurotransmitters (such as serotonin, norepinephrine and dopamine), resulting in symptoms such as persistent anxiety, palpitations, lack of concentration and muscle tension.

🧠 Physiological mechanisms of anxiety disorders :

•       The brain's amygdala becomes overactive, leading to excessive worry and tension.

•       High levels of cortisol (the stress hormone) put the body into a “ fight or flight ” state.

•       Imbalanced serotonin ( 5-HT ) levels , increasing anxiety and mood swings.

 

Tandospirone citrate (セディール): a safe and non-addictive anxiety treatment drug

🔹 Tandospirone citrate ( Tandospirone , セディール) is a non-benzodiazepine anxiolytic that acts primarily on the 5-HT1A receptor and reduces anxiety by enhancing serotonin signaling.

Tandospirone Citrate vs. Traditional Anti-Anxiety Drugs

•       Unlike benzodiazepines (eg, alprazolam, lorazepam), tandospirone does not cause dependence or withdrawal ( Stein et al., 2018 ).

•       It has fewer side effects, does not affect cognitive ability, and is suitable for long-term use .

•       It is effective for generalized anxiety disorder ( GAD ) and social anxiety disorder ( SAD ) and does not affect daytime activities .

Clinical research data :

•       After taking tandospirone for 4 weeks, anxiety scores decreased by 55% ( Stein et al., 2019 ).

•       Compared with benzodiazepines (such as diazepam), tandospirone has a longer-lasting effect on relieving long-term anxiety ( Hirano et al., 2015 ).

💡 If you are looking for a non-addictive, long-term anti-anxiety medication, tandospirone citrate is an ideal choice!

Low-dose sulpiride (Dogurama): For patients with anxiety and mild depression

🔹 Sulpiride(Dogmachal) is an antipsychotic drug thathas good anxiolytic and mild antidepressant effects at low doses ( 50-100 mg/ day) and is particularly suitable for patients with anxiety.

Sulpiride's unique mechanism of action :

✅ At low doses, it can enhance dopamine function and help relieve anxiety and depression.

✅ Suitable for gastrointestinal discomfort caused by anxiety (such as irritable bowel syndrome) .

✅ It will not cause dependence on benzodiazepines, but it must be used under the guidance of a doctor .

Clinical research data :

•       Low-dose sulpiride can reduce anxiety scores by 60% ( Richelson, 1999 ).

•       It is suitable for patients with anxiety accompanied by mild depression, gastrointestinal dysfunction, and neuralgic headaches ( Lader et al., 2013 ).

 

Tandospirone citrate vs. low-dose sulpiride: which one to choose?

Drug Name	Main Function	Suitable for	Is there any dependency?
Tandospirone citrate	Regulates the serotonin system and reduces anxiety	Generalized anxiety disorder ( GAD ), social anxiety disorder ( SAD )	❌ No dependencies
Low dose sulpiride	Regulate the dopamine system to relieve anxiety and mild depression	Patients with anxiety + mild depression, gastrointestinal discomfort	❌ No dependencies

How to choose?

✅ If the main problem is anxiety disorder ( GAD , social anxiety) without depression → Tandospirone citrate is the first choice (fewer side effects, suitable for long-term use).

Instructions and precautions

How to take Tandospirone Citrate :

✅ Recommended dose: 10-30 mg/ day, divided into 2-3 doses .

✅ After taking it for 2-4 weeks, the anxiety gradually decreases, and long-term use is recommended .

✅ It can be used in combination with SSRI/SNRI to improve the anxiety relief rate .

How to take low-dose sulpiride :

✅ Recommended dose: 50-100 mg/ day, usually taken in the morning to avoid drowsiness.

✅ Long-term use should be carried out under the guidance of a doctor to avoid sudden discontinuation of the drug .

 

Safe, non-addiction-free anxiety treatment options

If you are experiencing long-term anxiety and are looking for a non-addictive treatment option that does not affect your daily activities, tandospirone citrate and low-dose sulpiride may be a good choice!

✅ Tandospirone citrate is suitable for patients with long-term anxiety, has no risk of addiction, and is suitable for generalized anxiety and social anxiety.

✅ Low-dose sulpiride is suitable for patients with anxiety accompanied by mild depression or gastrointestinal dysfunction.

It is recommended to consult a professional doctor to find the recovery path that best suits you!

Choose medicines scientifically to effectively relieve your anxiety and regain your inner peace!

 

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