Will there be a rebound after stopping tipol? How to maintain weight loss results in the long term?

Tilboride is hailed as the most potent FDA -approved weight-loss drug currently available . In a 72- week clinical trial, patients experienced an average weight loss of 22.5% , with 57% losing more than 20% . However, many users worry: Will the weight rebound after discontinuing tilboride? How can they maintain their weight loss results long-term?

This article will analyze weight management issues after discontinuing telpolide and provide scientific methods, including dietary adjustments, exercise strategies, and lifestyle optimization , to help you maintain your ideal weight and avoid rebound after stopping the medication.

 

1. Will my weight rebound after I stop using telpoide?

📌 The essence of weight rebound: the balance between calorie intake and expenditure. 
The reason why telpoeptide can help people lose weight is that it reduces appetite, slows gastric emptying, and increases fat burning through a dual GLP-1 + GIP agonist mechanism , allowing people to actively consume less calories while burning more fat .

However, if good lifestyle habits are not developed after stopping the medication, the previously suppressed appetite may return, leading to increased calorie intake and weight gain.

📌 Clinical research data: Weight changes after drug discontinuation

🔍 SURMOUNT-4 Study (Weight Changes After Discontinuation of Telboride) :

•       After 72 weeks, all subjects lost 20-22% of their body weight and were then randomly assigned to either continue medication or discontinue medication .

•       Those who continued medication maintained their weight loss , while those who stopped medication regained an average of 14.5% of their weight within a year .

•       However, it is still about 10-12% lower than the starting weight , indicating that the long-term effects of telpolide are still present.

📌 Key findings

✔ After completely stopping the medication, appetite may partially return and weight may rebound , but it usually will not return to the original weight level.

✔ If you maintain healthy eating and exercise habits after stopping medication, your weight can be maintained in the long term, and the rebound rate will be greatly reduced.

💡 Conclusion: If diet and exercise are not adjusted after stopping medication, some people will experience weight rebound. However, a proper lifestyle can effectively control the rebound and maintain long-term weight loss results.

 

2. How to maintain weight loss results long-term and avoid rebound?

📌 The key to maintaining weight is:

•       Establish a long-term sustainable diet and avoid reverting to a high-calorie diet.

•       Stick to a scientific exercise plan to increase your basal metabolic rate and prevent fat from accumulating again.

•       Manage your appetite and psychological factors to avoid weight regain due to emotional eating.

 

2.1. Dietary adjustments: How to eat healthily and prevent appetite rebound?

📌 The goals of dietary control :

✔ Prevent excessive calorie intake and avoid overeating .

✔ Ensure adequate protein intake to prevent muscle loss and boost basal metabolism .

✔ Reduce your intake of refined carbohydrates to stabilize blood sugar and reduce hunger .

Best Dietary Strategy

✔ High-protein diet (accounting for 25-30% of total calories):

•       Why? High protein intake can increase satiety, maintain muscle mass, and boost basal metabolism .

•       Recommended foods : chicken breast, fish and shrimp, eggs, Greek yogurt, beans, etc.

✔ Low-refined carbohydrates (to avoid drastic blood sugar fluctuations) :

•       Why? Refined carbohydrates (such as white rice and white bread) cause insulin spikes, leading to a stronger feeling of hunger .

•       Recommended alternatives : low -GI carbohydrates such as brown rice, whole wheat bread, quinoa, and sweet potatoes.

✔ Healthy fats (help maintain hormone balance) :

•       Recommended foods : avocado, olive oil, nuts, deep-sea fish.

💡 Conclusion: Maintaining a high-protein, low-refined-carbohydrate diet after discontinuing medication can effectively reduce appetite rebound and lower the likelihood of weight gain.

 

2.2. Exercise Plan: How to maintain weight through exercise?

📌 The three major functions of exercise

✔ Preventing a drop in basal metabolic rate : Muscle loss reduces metabolism, while exercise can maintain muscle mass and sustain higher energy expenditure .

✔ Help burn fat : Combining aerobic exercise with strength training can improve the body's fat-burning ability.

✔ Improve insulin sensitivity : reduce blood sugar fluctuations, decrease appetite, and prevent the risk of diabetes.

📌 Optimal Exercise Strategy

1️ Aerobic exercise ( 3-5 days a week)

✔ Recommended exercises : brisk walking, jogging, cycling, swimming, 30-45 minutes each time.

✔ Function : Improves cardiorespiratory endurance and helps with sustained fat burning.

2️ Resistance training ( 2-3 times per week)

✔ Recommended training : squats, deadlifts, dumbbell exercises, and core training.

✔ Effects : Increases muscle mass, boosts basal metabolism, and reduces weight regain.

💡 Conclusion: Maintaining exercise 3-5 days a week after stopping medication can effectively reduce fat accumulation and improve the weight loss maintenance rate.

 

2.3. How to adjust one's mental state and avoid emotional eating?

📌 Psychological problems that may occur after stopping medication

•       " I can go back to a normal diet now " → resulting in overeating and weight gain.

•       " Feeling anxious about gaining a little weight " → Excessive dieting leads to a more severe rebound in appetite.

📌 Response strategies

✔ Set long-term goals, not short-term weight numbers (focus on body composition and health indicators).

✔ Record your daily diet and exercise to establish good habits .

✔ Find alternative ways to cope with stress (yoga, meditation, instead of overeating).

💡 Conclusion: Psychological management is an important part of maintaining weight in the long term, establishing sustainable eating and exercise habits rather than relying on short-term extreme methods.

 

3. Conclusion: How to maintain long-term weight loss after stopping medication?

📌 After discontinuing telpolide, some people may experience some degree of weight rebound if they do not adjust their lifestyle. However, the following strategies can effectively prevent this:

✔ Maintain a high-protein, low-refined-carbohydrate diet to reduce appetite rebound .

✔ Stick to aerobic and resistance training 3-5 days a week to boost metabolism and prevent weight regain .

✔ Manage your psychological expectations and avoid excessive dieting or binge eating due to anxiety .

💡 Final conclusion: The weight loss effect of telpolide can be maintained in the long term, but the key is to develop good eating and exercise habits, establish a sustainable health management strategy, and avoid dependence on drugs.