Semaglutide is already very good, why do some people switch to Mounjaro?
Semaglutide (trade name Wegovy , Ozempic ) is a GLP-1 receptor agonist widely used in the market, which has been proven to effectively help weight loss and improve metabolism . However, since the launch of Mounjaro (tebuconazole), more and more users and doctors have begun to choose Mounjaro , and even switched from semaglutide to Mounjaro .
Is Mounjaro really better? What are its advantages? Why are more and more people choosing to switch from semaglutide?
1. Mounjaro vs. semaglutide: core differences in mechanism of action
Semaglutide is a GLP-1 receptor agonist that achieves weight loss and blood sugar control mainly by reducing appetite, delaying gastric emptying, and reducing glucagon secretion .
Mounjaro is a GLP-1 + GIP dual receptor agonist . Compared with semaglutide, it has an additional GIP receptor stimulatory effect and performs better in improving fat metabolism and insulin sensitivity .
|
Key Factors |
Mounjaro (tepoltide) |
semaglutide ( Wegovy/Ozempic ) |
|
Mechanism of action |
GLP-1 + GIP dual agonist |
GLP-1 monoagonist |
|
Appetite suppression |
powerful |
powerful |
|
Promotes fat decomposition |
Yes ( GIP function) |
None (calorie reduction only) |
|
Improved insulin sensitivity |
Stronger ( GIP effect) |
Some improvement |
|
Long-term weight loss effects |
Stronger, with an average decrease of 22.5% |
Down 16.9% |
|
side effect |
Less gastrointestinal discomfort and better tolerance |
Some people experience severe nausea and vomiting |
|
Suitable for long-term use |
yes |
yes |
Mounjaro is superior in weight management, metabolic improvement, and long-term maintenance effects , so more and more people are switching from semaglutide to Mounjaro .
2. Semaglutide vs. Mounjaro : Comparison of clinical data
• SURMOUNT-1 study ( Mounjaro ): After 72 weeks, the average body weight reduction in the Mounjaro 15 mg group was 22.5% , and some subjects lost more than 25% of their body weight.
• STEP-1 study (semaglutide): After 68 weeks, the average body weight reduction in the Wegovy 2.4mg group was 16.9% , which was 5.6% lower than that of Mounjaro .
• The blood sugar control in the Mounjaro group was more stable and the improvement in insulin sensitivity was more obvious, which is suitable for people with prediabetes and metabolic abnormalities.
Data show that Mounjaro has a stronger weight loss effect than semaglutide and is better at maintaining body weight in the long term.
3. Why are more and more people switching from semaglutide to Mounjaro ?
( 1 ) Stronger weight loss effect, suitable for people with high BMI
• For obese patients with a BMI of 30 or above , Mounjaro provided greater weight loss ( 22.5% vs. 16.9% ).
• For people who have used semaglutide but have not responded well , Mounjaro provides a better option.
( 2 ) Fat decomposition is more efficient, not just about “ eating less ”
• While semaglutide primarily reduces caloric intake , Mounjaro also promotes fat breakdown , leading to faster reduction of body fat.
• This gives Mounjaro an advantage in terms of reducing abdominal fat and improving insulin resistance .
( 3 ) Fewer side effects and easier to stick to
• Common side effects of semaglutide include nausea, vomiting, and stomach discomfort , and some patients find it difficult to take it for a long time.
• Mounjaro has relatively mild gastrointestinal side effects , and some people may be able to tolerate and persist in using it more easily.
( 4 ) Improve metabolic abnormalities and achieve better long-term health management
• Mounjaro additionally improves the GIP receptor , making it more effective than semaglutide in terms of insulin sensitivity, blood sugar control, and cardiovascular health .
• Suitable for people with metabolic syndrome such as prediabetes, hyperlipidemia, and hypertension .
( 5 ) The weight maintenance effect is more stable and the risk of regaining weight is reduced
• Some people experience weight regain after stopping semaglutide . Mounjaro has better long-term maintenance effects due to improved metabolism.
• Clinical data show that even after discontinuation of Mounjaro , the risk of weight rebound is lower than that of semaglutide .
4. Semaglutide vs. Mounjaro : Should you switch?
📌 Mounjaro is suitable for the following people:
Hoping to achieve greater weight loss (goal is more than 20% weight loss) .
I am not satisfied with the weight loss effect of semaglutide and hope to find a more effective solution .
Gastrointestinal tolerance is poor, and we hope to reduce side effects such as nausea and vomiting .
Have insulin resistance, prediabetes or metabolic syndrome and need to improve blood sugar and fat metabolism .
📌 If your goal is moderate weight loss ( 10-15% body weight loss) and you can tolerate the side effects of Wegovy , then continuing to use Wegovy will meet your needs.
If you are looking for a more efficient and stable weight loss effect, while reducing side effects and improving long-term metabolic health, Mounjaro is a better choice.
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