Can't sleep? It's not because you are too nervous, but because your wakefulness system is too active! - In-depth analysis of the scientific principles of new sleeping pills
1. Why can’t you fall asleep the more tired you are? The root cause may be in the “ awakening system ”
Many people think that they suffer from insomnia because of " too sensitive nerves ", " too much pressure " and " the brain cannot be turned off " , but this is just an appearance. In fact, modern neuroscience research has found that there is a powerful wakefulness maintenance system in the brain - the orexin system , which determines when we should be awake and when we should fall asleep.
📌 When this system is overactive, the brain has trouble “ switching into sleep mode ” even when the body is tired and the environment is quiet. This is the core problem for many insomniacs.
2. What is the orexin system? Why does it determine whether you can fall asleep?
Orexin is a neuropeptide secreted by the hypothalamus that is responsible for regulating wakefulness, alertness, and energy maintenance. It " sends wakefulness signals " to the brain through two receptors, OX1R and OX2R .
In healthy people:
• Daytime: Orexin is active, keeping you awake
• Night: Orexin activity decreases and the brain gradually enters sleep mode
However, in many patients with chronic insomnia, orexin secretion is abnormal and the arousal pathway cannot be " turned off " , resulting in the inability to fall asleep or the brain quickly awakening after waking up in the middle of the night .
3. A new generation of sleeping pills: not " sedation " but " regulating wakefulness "
Traditional sleeping pills (such as benzodiazepines and zopiclone) act on the GABA system and achieve sedation and hypnosis by inhibiting the central nervous system , but there are side effects such as the risk of addiction, disruption of sleep structure, and morning drowsiness.
The new generation of sleeping pills, such as:
• Suvorex
• Leibersson
• Dale Raisin
Orexin Receptor Antagonists (ORAs ) block OX1R and OX2R receptors, reducing the transmission of wakefulness signals and allowing the brain to naturally enter a resting state .
📌 Simply put, they " turn off the alarm " rather than " give the brain anesthesia. "
4. Differences in mechanism determine differences in efficacy
|
project |
Traditional sleeping pills |
Orexin antagonists (such as Suvorexant) |
|
Target |
GABA system |
OX1R/OX2R Awakening System |
|
Does it calm the brain? |
yes |
no |
|
Does it disrupt sleep structure? |
yes |
no |
|
Addiction risk |
have |
none |
|
Daytime effects |
Drowsiness and decreased concentration |
Stay awake and hangover-free |
|
Suitable for long-term use |
no |
yes |
📌 Data support:
• Suvorex was used for 12 months and there was no rebound insomnia after discontinuation of the drug ( Sun et al., 2021 )
• A 6 -month clinical study of Lebrexan showed that sleep structure was not disrupted and the proportion of deep sleep increased ( Ueno et al., 2022 )
• Dauvilliers et al., 2022
5. Conclusion: To fall asleep, you don’t need to “ stay up all night ” , but rather “ turn off the wakefulness button in your brain ”
The reason you can’t sleep is not because you don’t have enough willpower or that your body is not tired, but because your brain is “ not ready to rest ” .
The new generation of sleeping pills no longer force sedation, but gently regulate the wakefulness system through scientific mechanisms, allowing you to return to your natural sleep rhythm .
If you are troubled by " the more tired you are, the more awake you feel " and " waking up in the middle of the night and having trouble falling asleep " , you might want to learn about Suvorexant, Lebrexant or Darilexant, and find your deep sleep under the guidance of a professional doctor.
🛒Leborexant 2.5mg 100 tablets / box
🛒Lebrexan 5mg 100 tablets / box
🛒Leborexant 10mg 100 tablets / box
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