"I'm so tired but I just can't fall asleep?" Explain the scientific reasons for overactive brain before bedtime and ideas for drug intervention

1. Why does the brain keep working even when the body is tired?

This phenomenon of " being tired but unable to sleep " is not uncommon, especially in:

•       High-pressure workplace people (difficult to switch emotions after get off work)

•       Active thinking individuals (thinking, anxious)

•       Those who process a lot of information during the day and have mood swings

The essence of this is that the awakening system is continuously activated and not shut down in time :

•       The Orexin system in the hypothalamus controls the onset and maintenance of wakefulness

•       In states of anxiety or stress, the OX1R/OX2R pathway continuously releases “ wakefulness signals ”

•       This allows the brain to remain in " daytime mode " even when the body feels tired.

📌 Simply put, your brain " thinks you're still dealing with the problem " and doesn't allow you to fall asleep.

 

2. Why is it difficult for traditional sleeping pills to solve " brain overactivity type insomnia " ?

Traditional benzodiazepines or non-benzodiazepine sleeping pills (such as diazepam and zopiclone) mainly inhibit neurotransmitter activity by enhancing GABA-A , thus playing a sedative and hypnotic role. Their problems are:

•       Falling asleep quickly, but not necessarily naturally (more like being " turned off " )

•       Affects deep sleep structure ( N3 stage decreases, more dreams)

•       Long-term use can easily lead to dependence, tolerance, and rebound insomnia

•       Often accompanied by dizziness and decreased concentration the next day

📌 These drugs aim to " make you fall asleep " but do not address the question of " why you can't sleep " .

 

3. Suvorexan and Lebrexan: Starting from the wakefulness regulation mechanism, helping the brain to naturally " turn off the lights "

🔹 Suvorexant: Suitable for people with " difficulty falling asleep + waking up at night "

•       By blocking OX1R and OX2R receptors, it reduces the activity of the arousal system

•       Reduce wakefulness signals in the brain and induce natural sleepiness

•       At the same time, it has a certain ability to maintain sleep and reduce the number of awakenings at night

•       Suitable for people with excessive thinking and anxiety, and those who sleep lightly

🔹 Lebrexan: Fast-acting, suitable for people who have trouble falling asleep

•       The pharmacological mechanism is the same as Suvorexant, but it focuses more on rapid induction of sleep

•       Suitable for those who have difficulty falling asleep for a long time or cannot fall asleep after being emotionally excited

•       Does not inhibit the central nervous system and does not affect the sense of wakefulness the next day

drug	Mechanism of action	Onset of Effect	Addictive	Suitable for
Suvorex	Blockade of OX1R/OX2R	medium	none	Difficulty falling asleep + night wakings
Leibersson	Blockade of OX1R/OX2R	fast	none	Slow to fall asleep + anxious

4. Scientific research supports: regulating the wakefulness pathway and effectively shortening the time to fall asleep

•       Krystal et al. (2021) : The average sleep onset time in the orexin antagonist group was shortened by 22 to 27 minutes , and the subjective " sense of falling asleep naturally " score was significantly improved

•       Ueno et al. (2022) : Lebrexan users showed improved sleep in the first week , without side effects such as dizziness and memory loss

•       There are no withdrawal symptoms or rebound insomnia after stopping the drug, which is suitable for short-term and medium-term adjustment.

 

5. Who should consider using this type of “ wakefulness-modifying ” sleep aid?

•       Excessive wakefulness and repetitive thinking at night, taking more than 30 minutes to fall asleep

•       Even though you are physically tired, you need to “ stay to the limit ” before you can fall asleep

•       Emotionally sensitive, anxious personality, difficulty relaxing before bed

•       Tried GABA drugs but the results were poor and worried about dependence

📌 If your problem is not " lack of sleep " but " inability to turn off your brain " , this type of medicine may be a scientific solution to changing your sleep logic.

 

Conclusion: Helping the brain to sleep should not be about knocking you out, but about helping the brain “ go off duty ” naturally

Anxiety-type insomnia is not just a problem of not being able to sleep, but also a problem of the brain working overtime . Suvorexan and Lebrexan regulate the arousal mechanism, not suppressing the brain, but gently guiding it to end its daytime operation and enter the night rhythm .
It’s not that you don’t want to sleep, it’s that your wakefulness system has not been properly appeased - and now, there is a solution.

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