Will it be difficult to quit taking it for a long time? A complete analysis of the dependence and tolerance of new sleeping pills!
1. Why do people worry about not being able to quit taking sleeping pills?
Many people think of a few words when they mention sleeping pills:
• Can’t stop eating once you start?
• Will you eat more and more?
• Can't sleep after stopping medication?
• What to do if you become a " medicine jar " ?
📌 These concerns are not groundless. Benzodiazepine sleeping pills (such as diazepam and alprazolam) do have addiction and tolerance problems , which makes many patients reluctant to take sleeping pills.
2. Why are traditional sleeping pills so addictive?
The mechanism of action of benzodiazepines is to enhance the activity of GABA-A receptors and achieve the effect of falling asleep quickly by calming the brain's nervous system.
However, long-term use will cause the following problems:
|
risk |
reason |
|
Dependencies |
The brain adapts to drug stimulation and it is difficult to fall asleep on your own after stopping taking the drug |
|
Tolerance |
The effect is decreasing, and the dosage needs to be increased continuously to maintain the original effect |
|
Rebound insomnia |
Insomnia worse after stopping medication ( Lader, 2011 ) |
|
Cognitive side effects |
Long-term use affects memory, attention, and brain plasticity ( Billioti de Gage, 2014 ) |
📌 Medical guidelines have clearly recommended that benzodiazepines should not be used for a long time and continuous use should be limited to 2-4 weeks.
3. Why won’t the new generation of sleeping pills make you addicted ? The mechanism determines its safety
Suvorexant, Lebrexant, and Darilexant are orexin receptor antagonists ( ORAs ) , and their core principle is:
• Blocking OX1R and OX2R receptors → weakening arousal signals
• Does not affect the GABA system → does not calm or inhibit core brain activity
• Does not involve reward / dopamine pathways → does not create psychological dependence
📌 In other words, they help the brain to " shut down naturally " rather than " force it to shut down. "
4. Scientific data support: safe for long-term use, no rebound after discontinuation of medication
Many clinical trials have proven that the new generation of sleep aids have no obvious dependence and tolerance issues :
|
drug |
Clinical research results |
|
Suvorex |
After 12 months of continuous use, there was no significant decrease in sleep quality after discontinuation of the medication ( Sun et al., 2021 ) |
|
Leibersson |
There was no tolerance after 6 months of use, and no rebound insomnia after discontinuation of medication ( Ueno et al., 2022 ) |
|
Dale Raisin |
No effect on cognitive function, no drug accumulation problem, and stable state after drug discontinuation ( Dauvilliers et al., 2022 ) |
In addition, these drugs do not suppress REM and deep sleep, helping to establish a stable, natural sleep rhythm , which is beneficial for long-term improvement of sleep quality.
5. Health advice: Scientific medication + sleep management is the best solution
Even for safe new drugs, it is recommended to use them in conjunction with the following methods:
• Take medication under the guidance of a doctor
• Establish a regular work and rest schedule to avoid staying up late and having irregular work and rest schedules
• Reduce blue light stimulation before bedtime (such as mobile phones, computers)
• Appropriate exercise and relaxation training (such as meditation, breathing techniques)
📌 The correct role of sleeping pills: not to replace sleep, but to help you “ regain your rhythm ” .
6. Conclusion: Scientific drugs will not make you lose control of your sleep
The emergence of Suvorexant, Lebrexant, and Darilexant represents the transformation of sleeping pills from " suppression " to " regulation ." They are not addictive or out of control, but help you get rid of the old way of relying on sedation.
📌 Don't miss out on a truly scientific, gentle and sustainable sleep aid program because of your past " fear of drugs " .
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