GLP-1 single agonist vs. GLP-1/GIP dual agonist: Why is tepote better?
In recent years, GLP-1 receptor agonists have become the core drugs for the management of obesity and type 2 diabetes. Among them, GLP-1 single agonists such as semaglutide ( Wegovy , Ozempic ) have been widely used and have shown good weight loss and glucose control effects. However, as the first GLP-1/GIP dual agonist, telopoietin ( Mounjaro/Zepbound ) not only surpasses semaglutide in weight loss effect, but also excels in tolerability and metabolic improvement .
So, what is the essential difference between GLP-1 monoagonists and GLP-1/GIP dual agonists? Why is tepote better for weight loss? This article will analyze in detail why tepote has become the strongest GLP-1 weight loss drug at present through its mechanism of action, clinical research data, and side effect comparison.
1. GLP-1 single agonist vs. GLP-1/GIP dual agonist: fundamental difference in mechanism of action
( 1 ) GLP-1 receptor agonist (semaglutide)
Main functions :
• Reduce appetite : Act on the appetite center of the hypothalamus in the brain, reduce hunger, and make people actively reduce food intake.
• Delays gastric emptying : Increases satiety and allows food to stay in the stomach longer, thereby reducing the amount of food eaten.
• Promote insulin secretion and lower blood sugar : suitable for people with diabetes and metabolic abnormalities.
limitation :
• It mainly relies on reducing appetite, with limited effects on fat breakdown and energy expenditure , resulting in slower weight loss in some patients.
• Gastrointestinal side effects (nausea, vomiting, diarrhea) are strong and some patients may find it difficult to tolerate them for a long time.
( 2 ) GLP-1/GIP dual agonist (tepoltide)
In addition to the effects of GLP-1 , GIP receptor agonism brings additional advantages :
• It promotes fat decomposition, increases metabolic rate , acts directly on fat cells, accelerates fat oxidation, and makes weight loss faster and more stable.
• Enhance insulin sensitivity and reduce insulin resistance, which is more beneficial for patients with prediabetes and diabetes.
• Reduce the gastrointestinal side effects of GLP-1 drugs , improve patient tolerance, and improve long-term compliance.
Conclusion : GLP-1 mainly relies on reducing calorie intake , while the GIP effect of telportin can also promote fat consumption, improve metabolism, and enhance tolerance , thereby optimizing the weight loss effect from multiple aspects.
2. Comparison of clinical research data: telpotide vs. semaglutide
|
Research |
Tipollution ( GLP-1/GIP dual agonist) |
Semaglutide ( GLP-1 monoagonist) |
|
Weight loss (average) |
22.5% weight loss after 72 weeks ( SURMOUNT-1 study) |
16.9% weight loss after 68 weeks ( STEP-1 study) |
|
Proportion of people with weight loss ≥ 20% |
57% |
36% |
|
Maximum weight loss |
Up to 27% |
Up to 18% |
|
Target Group |
Obese and overweight patients with metabolic abnormalities |
Obese and diabetic patients |
📌 Data Analysis :
• The average weight loss of tebuconazole in the same period was 5.6% higher than that of semaglutide , and the long-term weight loss effect was stronger.
• More than 57% of patients lost more than 20% of their body weight , compared with only 36% for semaglutide.
• Tipoline not only reduces appetite, but also accelerates fat decomposition, making it the strongest weight loss drug currently approved by the FDA .
3. Side effect comparison: Which one is better tolerated?
|
Side effect category |
Tipollution ( GLP-1/GIP dual agonist) |
Semaglutide ( GLP-1 monoagonist) |
|
nausea |
31% |
44% |
|
Vomit |
18% |
twenty four% |
|
diarrhea |
twenty one% |
30% |
|
constipate |
14% |
17% |
📌 in conclusion :
• The GIP effect of tepoxetine can reduce the common gastrointestinal side effects of GLP-1 drugs and improve patient tolerance.
• Compared with semaglutide, telpotide has lower incidences of nausea, vomiting, and diarrhea, and is easier to maintain during long-term use.
4. Telbutide vs. semaglutide: Which one is better for you?
📌 If your goal is maximum weight loss ( >20% body weight loss)
✔ Telbutaline is currently the strongest choice , with a weight loss of up to 22.5%-27% , far exceeding semaglutide.
📌 If you have had difficulty adhering to GLP-1 medication due to side effects (nausea, vomiting)
✔ The GIP effect of tepoxetine can reduce gastrointestinal side effects, improve tolerance , and make it more suitable for long-term use.
📌 If your main concern is sugar control (such as diabetics)
✔ Both semaglutide and telpotide can effectively lower blood sugar , but telpotide has a stronger effect on improving insulin sensitivity and is more advantageous for patients with prediabetes.
💡 Final conclusion : Telpotide is superior to semaglutide in weight loss effect, tolerability and metabolic improvement, and is the strongest FDA- approved GLP-1 weight loss drug on the market.
🛒Mounjaro 2.5mg *2 sticks / box*2
Eli Lilly's official website introduces telportipeptide ( EN )
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