What is telpotide? ——Analysis of the core mechanism of the new generation of weight loss drugs
1. What is telpotide?
Tirzepatide (trade name Mounjaro ) is a new generation of GLP-1 + GIP dual receptor agonist . It was originally developed by Eli Lilly for the treatment of type 2 diabetes , but it has shown unprecedented weight loss effects in weight management , becoming a breakthrough product in the weight loss drug market in recent years.
Unlike traditional GLP-1 receptor agonists (such as semaglutide Wegovy/Ozempic ), telpotide acts on both GLP-1 and GIP incretin receptors , enhancing the ability to suppress appetite, improve metabolism, and promote fat consumption , and therefore performs more effectively in weight loss.
📌 Core Features:
✅ Dual agonist action ( GLP-1 + GIP ), more potent than single GLP-1
✅ Significant weight loss effect , research shows that it can reduce body weight by 22.5% ( SURMOUNT-1 study)
✅ Also improves insulin sensitivity , helping prevent diabetes
✅ Reduce hunger, reduce food intake , and regulate energy balance
✅ Delaying gastric emptying and reducing blood sugar fluctuations can help with long-term weight control
2. GLP-1 receptor agonists ( Glucagon-Like Peptide-1, glucagon-like peptide -1 ): How to help weight loss?
GLP-1 is a naturally secreted incretin hormone in the human body, which is released by the intestinal L cells after eating. GLP-1 receptor agonists are a class of drugs that mimic the effects of GLP-1 and help lose weight mainly in the following ways:
🔹 Suppress appetite : GLP-1 acts on the hypothalamic appetite regulation center of the brain, reducing hunger and causing people to naturally reduce food intake .
🔹 Delaying gastric emptying : GLP-1 can reduce gastric motility , causing food to stay in the stomach longer, resulting in a longer-lasting feeling of fullness and reducing the frequency of eating.
🔹 Promote insulin secretion and lower blood sugar : GLP-1 mainly promotes insulin secretion after eating , helping the body to better utilize blood sugar and avoid converting excess energy into fat storage.
🔹 Reduced glucagon release : Lowering glucagon levels reduces the release of glucose by the liver, which helps control blood sugar levels.
GLP-1 receptor agonist representative drugs :
🔹 semaglutide ( Wegovy/Ozempic )
🔹 liraglutide ( Saxenda )
🔹 dulaglutide ( Trulicity )
📌 Comparison of GLP-1 effects of telpotide vs. semaglutide Although semaglutide ( Wegovy ) is also a GLP-1 receptor agonist and has achieved good results in weight loss (average weight loss of 16.9% ), tepoxetine not only acts on the GLP-1 receptor, but also activates the GIP receptor , resulting in a stronger metabolic effect.
3. GIP receptor agonists ( Glucose-Dependent Insulinotropic Peptide ): How to enhance weight loss effects?
GIP receptor agonist is the unique advantage of tilpotide. Before this, other weight loss drugs (such as semaglutide) only acted on GLP-1 , and the addition of GIP receptor agonist makes tilpotide more powerful in metabolic regulation.
🔹 Promote insulin secretion (only works when blood sugar is high, reducing the risk of hypoglycemia)
🔹 Improve insulin sensitivity and reduce insulin resistance (especially suitable for overweight and metabolically abnormal patients)
🔹 Directly promotes fat decomposition , helps reduce body fat and improves energy consumption
🔹 Reduces inflammation , which may help lower chronic inflammatory responses associated with obesity
📌 Why can GIP receptor agonists enhance weight loss effects?
GIP not only enhances the glucose-lowering effect of GLP-1 , but also regulates fat metabolism , allowing the body to break down fat more effectively rather than storing excess energy. Therefore, the dual effects of GLP-1 + GIP make tepoxetine far more effective in weight loss than a simple GLP-1 receptor agonist .
4. What is the weight loss effect of tebuconazole? (Clinical data)
The latest SURMOUNT-1 study ( 2022 ) confirmed the excellent performance of tebuconazole in weight loss:
📊 72- week weight loss effect (weight loss % ):
|
Group |
Telpotide 5mg |
Telpotide 10mg |
Telpotide 15mg |
Placebo |
|
Average weight loss |
15.0% |
21.4% |
22.5% |
2.4% |
💡 Compared with semaglutide ( Wegovy ):
• Semaglutide ( Wegovy ) achieved a maximum weight loss of 16.9% ( STEP-1 study)
• The average weight loss in the 15mg group of tebuconazole was 22.5% , which was nearly 5.6% higher than that of Wegovy.
• More than 60% of patients lost more than 20% of their body weight , which is much higher than the GLP-1 drugs currently on the market.
📌 Conclusion: The weight loss effect of telportide far exceeds that of GLP-1 monoagonists and is particularly suitable for users who want to achieve greater weight loss
5.Who is suitable for using tepote?
✅ Overweight / obese people who want to lose weight scientifically ( BMI ≥ 30 )
✅ BMI ≥ 27 and accompanied by metabolic diseases (such as hypertension, hyperlipidemia, prediabetes)
✅ Patients with type 2 diabetes need to control both blood sugar and weight
✅ Patients who have not responded well to other GLP-1 drugs (such as semaglutide)
⚠️ Not suitable for:
❌ People with a family history of medullary thyroid cancer
❌ Patients with severe gastrointestinal diseases (such as severe gastroparesis)
❌ Pregnant women or women trying to get pregnant (currently lacking safety studies)
6. Why is tepoxetine a breakthrough in the new generation of weight loss drugs?
🔹 GLP-1 + GIP dual agonist , providing stronger appetite suppression + enhancing fat metabolism
🔹 Compared with single GLP-1 (such as semaglutide), the weight loss effect is stronger (up to 22.5% )
🔹 Suitable for long-term use, with more controllable side effects , especially for people with diabetes and high metabolic risk
🔹 Already approved by FDA , with complete clinical trial data and high market recognition
📌 If you are looking for a scientific, safe and more effective weight loss solution, telopoietin may be one of the best choices currently.
👉 Pay attention to scientific weight loss and start by understanding telpotide!
--------------------------------
Welcome to add customer service to get new customer discount
Customer Service 1 ： AobMedical
Customer Service 2 ： Aob202404
Asakusa makeup: +81 8070566715 
