What is the weight loss effect of telopoietin? ——A comprehensive interpretation of the 72-week clinical study data
In the weight loss drug market, GLP-1 receptor agonists (such as semaglutide) have long been considered the most effective drug class. However, as the first GLP-1/GIP dual agonist, telopoietin far exceeds previous drugs in terms of weight loss and metabolic improvement.
So, what is the real weight loss effect of telpotide? Is it stronger than traditional GLP-1 drugs (such as semaglutide)? This article will combine the SURMOUNT-1 study to interpret the 72- week clinical data of telpotide in detail and comprehensively analyze how it achieves breakthroughs in weight loss, blood sugar reduction, and metabolic improvement .
1. SURMOUNT-1 study overview: weight loss data of tepoxetine
The SURMOUNT-1 study is the largest and most authoritative GLP-1/GIP weight loss drug clinical trial currently underway by Eli Lilly and Company, investigating the effects of telpotide on overweight and obese people.
📌 Research basics
• Participants : 2539 adults with BMI ≥27 (overweight) or BMI ≥30 (obese) without a history of diabetes.
• Trial duration : 72 weeks (approximately 1.5 years).
• Dosage regimen :
• Tipol 5mg , 10mg , 15mg groups (subcutaneous injection once a week).
• Placebo control group (no medication, just diet + exercise).
• Main objectives :
• To assess the effect of tepol on weight loss over 72 weeks.
• Observe its side effects, safety, and metabolic improvement effects .
📌 Summary of core data ( 15 mg tebuconazole group vs. placebo group):
|
index |
Telportide 15 mg group |
Placebo group |
Comparative advantages |
|
Weight loss (average) |
22.5% |
2.4% |
9 times gap |
|
Proportion of patients with weight loss ≥ 20% |
57% |
3.1% |
18 times gap |
|
Maximum weight loss |
27% |
5% |
5 times gap |
|
Waist circumference reduction |
Average reduction : 14.4 cm |
Only 3 cm |
Significantly reduces visceral fat |
💡 Conclusion: The average weight loss in the 15 mg tepoxetine group was 22.5% , far exceeding that of the placebo group (only 2.4% ), and 57% of the people lost more than 20% , making it the strongest weight loss drug approved by the FDA .
2. Telportide vs. Semaglutide: Which one has a better weight loss effect?
Currently, semaglutide is the strongest GLP-1 single agonist on the market . So , compared with telpotide ( GLP-1/GIP dual agonist), which one has a better weight loss effect?
📌 Comparison of SURMOUNT-1 (tepoxetine) and STEP-1 (semaglutide) study data :
|
drug |
Weight loss (average) |
Proportion of people with weight loss ≥ 20% |
Maximum weight loss |
|
Tipollide ( 15 mg ) |
22.5% |
57% |
27% |
|
Semaglutide ( 2.4 mg ) |
16.9% |
36% |
18% |
📌 Key findings :
✔ The mean weight loss with tebuconazole was 22.5% , which was 5.6% higher than that with semaglutide.
✔ 57% of patients lost ≥20% body weight, which was higher than with semaglutide ( 36% ).
✔ The highest weight loss rate reached 27% , far exceeding semaglutide ( 18% ).
💡 Conclusion: Telportide has a stronger weight loss effect than semaglutide, mainly because the GIP effect can promote fat burning, increase metabolic rate, and make weight loss faster and more stable.
3. In addition to weight loss, what other health indicators can telolipid improve?
Tipoleptide not only helps patients lose weight, but also significantly improves metabolic health and reduces the risk of multiple chronic diseases.
📌 The SURMOUNT-1 study showed that the metabolic improvement effects of the 15mg tepote group were as follows :
|
Health indicators |
Improve the situation |
|
Fasting blood sugar |
Decreased by 14.6 mg/dL (improved insulin sensitivity) |
|
Insulin resistance index ( HOMA-IR ) |
Reduced by 52% (reduced risk of diabetes) |
|
Blood pressure (systolic) |
Reduced by 7.2 mmHg (reduced cardiovascular risk) |
|
Cholesterol ( LDL ) |
Reduce by 10-15% (reduce the risk of atherosclerosis) |
|
Liver enzyme levels ( ALT , AST ) |
Reduced by 20% (improved fatty liver) |
📌 Core advantages :
✔ Prevent diabetes : Enhance insulin sensitivity and reduce the risk of prediabetes patients developing type 2 diabetes.
✔ Reduce the risk of cardiovascular disease : reduce the risk of high blood pressure, high cholesterol, and arteriosclerosis.
✔ Reduce fatty liver : Improve liver function by reducing visceral fat.
💡 Conclusion: Telpotide can not only help with weight loss, but also significantly improve health indicators such as blood sugar, blood lipids, and blood pressure, which is of great help to long-term health management.
4. Conclusion: The weight loss effect of tebuconazole far exceeds that of other drugs and has the advantage of improving metabolism
📌 Core conclusions :
✔ After 72 weeks, the average body weight decreased by 22.5% , and 57% of patients lost more than 20% of their body weight. The weight loss effect was better than all GLP-1 drugs.
✔ The weight loss effect is 5.6% higher than that of semaglutide, with the highest weight loss reaching 27% .
✔ Not only can it help you lose weight, it can also lower blood sugar, cholesterol, blood pressure, and reduce the risk of diabetes and cardiovascular disease.
💡 Bottom Line: If you want the most effective weight loss and improved overall metabolic health, telopoietin is by far the best choice.
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