Tipoline vs. other weight loss drugs: Comparison of clinical data, which one is more effective?
In recent years, the research and development of weight loss drugs have made major breakthroughs . From early appetite suppressants and fat absorption inhibitors to the current mainstream GLP-1 receptor agonists , different types of weight loss drugs have significant differences in effectiveness and safety.
Among them, telpotide , as the first GLP-1/GIP dual agonist , has demonstrated a weight loss effect far exceeding other drugs in clinical studies, becoming the strongest FDA -certified weight loss drug currently available.
So, what is the advantage of tirpotide over other weight loss drugs? What are its clinical data? Compared with other weight loss drugs such as semaglutide (Vigovi) and orlistat (Xenical), which one is more effective? This article will combine the SURMOUNT-1 study to compare the clinical data of different weight loss drugs to provide you with the most scientific basis for selection.
1. Current mainstream types of weight loss drugs
Currently, FDA -approved weight loss drugs mainly include the following categories:
|
Drug Class |
Main representative drugs |
Mechanism of action |
Main Features |
|
GLP-1 monoagonist |
Semaglutide (Vigovi), liraglutide (Saxeda) |
Acts on GLP-1 receptors , reduces appetite and delays gastric emptying |
Effective weight loss ( ~15% ), but gastrointestinal side effects are more obvious |
|
GLP-1/GIP dual agonists |
Telbutaline ( Mounjaro/Zepbound ) |
Activate GLP-1 and GIP at the same time, reduce appetite and promote fat metabolism |
Currently the most effective weight loss product ( >20% weight loss) with minimal side effects |
|
Fat absorption inhibitors |
Orlistat (Xenical) |
Inhibit lipase and reduce fat absorption |
Limited weight loss effect ( ~7% weight loss), prone to gastrointestinal discomfort (greasy stools, diarrhea) |
|
CNS appetite suppressants |
Amphetamines, naltrexone - bupropion |
Acts on brain neurotransmitters to reduce appetite |
Some drugs have been banned and have strong side effects (cardiovascular risks, addiction) |
📌 Key Differences :
• Traditional appetite suppressants and fat absorption inhibitors have limited weight loss effects (usually no more than 10% ) and many side effects, and have gradually been eliminated.
• GLP-1 drugs have become the most mainstream weight loss program at present . Among them , telpotide, as the only GLP-1/GIP dual agonist, is more effective than semaglutide .
2. Telbutaline vs. other weight loss drugs: comparison of clinical research data
📌 SURMOUNT-1 study (tebuconazole)
• Participants: 2539 adults with BMI ≥27 (overweight) or BMI ≥30 (obese) without a history of diabetes
• Dosing regimen: Telportide ( 5 mg , 10 mg , 15 mg ) once a week for 72 weeks
• Key results :
• The average weight loss in the 15mg group was 22.5% , which is the strongest weight loss effect certified by the FDA
• 57% of the subjects lost more than 20% of their body weight , significantly better than semaglutide
📌 STEP-1 study (semaglutide)
• Study subjects: 1961 adults with BMI ≥27 or BMI ≥30
• Dosing regimen: 2.4 mg semaglutide once a week for 68 weeks
• Key results :
• The average weight loss was 16.9% , which was a significant effect, but lower than that of telportolide.
• 36% of subjects lost more than 20% of their body weight , compared to 57% for tebuconazole
📌 XENICAL study (orlistat)
• Study subjects: Obese or overweight people, combined with a low-calorie diet
• Dosage regimen: 120 mg orlistat 3 times a day for 1 year
• Key results :
• Average weight loss is 7-10% , much lower than that of GLP-1 drugs
• The main side effects are diarrhea, oily stools, and gastrointestinal discomfort , which leads to low compliance
📌 Clinical data summary and comparison
|
drug |
Study Name |
Average weight loss (%) |
Proportion of people with weight loss ≥ 20% (%) |
|
Tipollide ( 15 mg ) |
SURMOUNT-1 |
22.5% |
57% |
|
Semaglutide ( 2.4 mg ) |
STEP-1 |
16.9% |
36% |
|
Orlistat |
XENICAL |
7-10% |
<10% |
in conclusion:
• The weight loss effect of tebuconazole is 5.6% higher than that of semaglutide and more than twice that of orlistat .
• A higher proportion of patients achieved a weight loss of ≥20% , making it easier for users to achieve significant weight loss goals .
3. Comparison of side effects and tolerability: Which drug is easier to stick to?
|
Side effect category |
Telportide ( GLP-1/GIP ) |
Semaglutide ( GLP-1 ) |
Orlistat (fat absorption inhibitor) |
|
Nausea and vomiting |
Mild ( 31% nausea, 18% vomiting) |
Severe ( 44% nausea, 24% vomiting) |
none |
|
Diarrhea / constipation |
May occur, but milder |
May occur, some people may not tolerate it |
Diarrhea and oily stools are common |
|
Hypoglycemia (in non-diabetic patients) |
Low |
Low |
none |
|
Long-term compliance |
Higher, good adaptability to side effects |
Some patients stopped taking the drug due to side effects |
Poor compliance, with discontinuation of medication due to gastrointestinal discomfort |
📌 Telportide is better tolerated
• The main side effect of GLP-1 drugs is gastrointestinal discomfort, but the GIP effect of tepoxetine can reduce nausea and vomiting and improve tolerance .
• Compared with semaglutide, tepoxetine has a lower incidence of side effects and is easier for users to adhere to the therapy for a long time .
• Orlistat has serious gastrointestinal side effects and poor long-term compliance, making it difficult for many patients to continue using it .
4. Which weight loss drug is the most effective?
📌 If the goal is maximal weight loss ( >20% body weight loss): Telbutaline is currently the strongest option .
📌 If you have had difficulty adhering to GLP-1 drugs due to side effects (nausea, vomiting) : The GIP effect of tepoxetine can reduce side effects and improve tolerability .
📌 If only mild weight loss or injection avoidance is needed : Orlistat is an alternative, but is far less effective than GLP-1 drugs .
💡 Final conclusion: Based on clinical data, tebuconazole is superior to other weight loss drugs in terms of weight loss effect, tolerability and long-term compliance, and is the strongest FDA -approved weight loss program on the market.
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Eli Lilly's official website introduces telportipeptide ( EN )
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