Reversing day and night, working overtime until late at night? This type of sleeping pill is suitable for restoring rhythm after staying up late

1. Staying up late or not being able to fall asleep after working shifts is actually because the " awakening system is not turned off "

Our brain sleep rhythm is mainly regulated by two major systems:

•       🕒 Circadian rhythm system (regulated by melatonin, etc., controlling " when you feel sleepy " )

•       ⚡ Wakefulness maintenance system (regulated by orexin, controls " when to wake up " )

Staying up late or working shifts for a long time can lead to:

•       Delayed or disrupted circadian rhythm (eg, melatonin levels still not elevated during the day)

•       The arousal system is overexcited, and the brain is still " on " even when the body is tired

•       Loss of physiological recognition of " sleep time " → rhythmic insomnia

📌 If you're still alert at 2 a.m. every morning, it means your brain has reset itself to the wrong " night wakefulness " mode .

 

2. Why can’t traditional sleeping pills help with “ dysrhythmia ” type insomnia?

Characteristics of traditional drugs represented by diazepam and zopiclone:

•       Forced sedation of the brain, fast hypnotic effect

•       Widespread effects, often accompanied by hangover, decreased concentration, and slowed reaction times

•       Without regulating the arousal system, it is impossible to correct the biological clock rhythm

•       Rebound insomnia is likely to occur after drug withdrawal

📌 For those who suffer from the type of insomnia that occurs when they stay up late and feel more awake the later it gets, traditional medicines “ lead to an unnatural sleep time ” .

 

3. ORAs : Not " knockout " but " restarting night mode "

Suvorexant, Lebrexant, and Darilexant are orexin receptor antagonists ( ORAs ) , and their working mechanism is:

•       Blocking OX1R/OX2R receptors in the brain inhibits the continuous release of wakefulness signals

•       Does not disrupt the GABA nervous system, does not inhibit cognition, and does not cause hangovers

•       Allows deep sleep to occur naturally, helping circadian rhythm restoration

 

4. Recommend two drugs that are more suitable for rhythm reconstruction

✅ Lemborexant : Rapid sleep onset, suitable for those with insomnia who are more awake as the night progresses

•       The onset time is short, which can significantly shorten the waiting time for falling asleep

•       Clinical data show that heart rate drops faster before bedtime and melatonin is secreted earlier ( Ueno et al., 2022 )

•       Suitable for workers who are " too excited after overtime and can't fall asleep when lying down "

✅ Suvorexant : A good way to sleep well all night, suitable for those who stay up late and often wake up halfway through the night

•       Long half-life ( 12 hours) to cover the entire night's sleep cycle

•       It is more effective for those who " go to bed early but wake up in the early morning " or start to have wild thoughts in the middle of sleep.

•       Several studies have confirmed that long-term use does not lead to addiction, and that sleep rhythms can be maintained after cessation of medication in patients with circadian rhythm disorders ( Sun et al., 2021 )

 

5. Suitable for long-term or phased use by the following groups of people

•       Long-term night shift and shift workers

•       Business people who frequently fly across time zones

•       Internet / creative design / programmers and other night-time workers

•       Having trouble falling asleep after staying up late, or waking up too early at night

•       Those who have tried melatonin or over-the-counter sleep aids but have not been effective

 

Conclusion: Rhythm disorder cannot be solved by " setting an alarm clock " , scientific intervention is more effective

It's not that you're not sleepy, it's that your brain isn't ready to rest . For disrupted sleep rhythms, the most important thing is to rebuild the neural conversion mechanism of " night wakefulness → night sleepiness " . ORAs such as Suvorexant and Lebrexant help you fundamentally " turn off the wakefulness system " and, without getting nervous or sedated, let you regain a sense of belonging at night in an untimely wakefulness .

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