With the help of treglitin succinate tablets, you can easily get rid of excess fat.
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When blood sugar-lowering drugs no longer contribute to weight gain but instead become an accelerator of fat metabolism, type 2 diabetes patients finally achieve a double victory in both blood sugar and weight.
Ms. Zhang stared at the steadily declining numbers on the scale, overwhelmed with mixed emotions. For the past two years, she had strictly controlled her blood sugar and desperately dieted, yet insulin treatment had caused her to gain a full 8 kilograms. What devastated her even more was that despite enduring the agony of hunger, her fasting blood sugar levels fluctuated wildly between 8 and 10 mmol/L —a reality faced by over 80% of patients worldwide using traditional hypoglycemic drugs.
But when she switched her insulin to trelagliptin succinate and adjusted her lifestyle, a miracle happened: she lost 7 kilograms in three months, her waistline shrank by 9 centimeters, and her fasting blood sugar stabilized between 5.6 and 6.5 mmol/L . What surprised her most was that she finally broke free from the psychological shackles of feeling guilty for eating even a single bite.
01 The Dilemma of Weight Loss for Diabetics: The Double Shackles of Medication and Metabolism
The weight gain trap of traditional drugs
● Insulin : Promotes the conversion of glucose into fat for storage; clinical data shows that patients gain 1-4 kg per year.
● Sulfonylureas : Overstimulate insulin secretion, leading to a similar weight gain effect.
● Thiazolidinediones : Cause water and sodium retention and visceral fat accumulation.
Vicious cycle of physiological mechanisms
Insulin resistance is the core obstacle: abnormal enlargement of fat cells → release of inflammatory factors → interference with insulin signaling → blood glucose cannot enter cells for energy → more sugar is converted into fat and accumulates, forming a vicious cycle of " the fatter you are → the higher your blood sugar is → the harder it is to lose weight ".
Even more disheartening is that strict dieting often backfires:
Hypoglycemia → Triggers a survival crisis in the brain → Increased hunger → High-carbohydrate binge eating → Weight rebound
Data shows that more than 70% of diabetics experience weight rebound within 3 months of dieting .
02 Breakthrough Tool: Deciphering the Fat-Reducing Mechanism of Trelagliptin
Intelligent Metabolic Regulation Engine
Trelagliptin, as the world's first once-weekly oral DPP-4 inhibitor , precisely avoids the weight gain trap of traditional drugs through its mechanism of action:
● ✅ Inhibit DPP-4 enzyme activity → Increase GLP-1 (glucagon-like peptide-1) levels
● ✅ Promotes insulin secretion on demand (activated only when postprandial blood glucose rises).
● ✅ Blocking excessive glucagon release → reducing hepatic glucose output
A molecular revolution in fat metabolism
A groundbreaking study in 2020 discovered that trelagliptin can directly activate the PI-3K/AKT signaling pathway in adipocytes , significantly increasing the expression of the following key proteins:
● GLUT4 glucose transporter : accelerates the uptake of glucose by adipocytes (for energy rather than fat storage).
● P-IRS-1 and P-AKT : Enhance insulin sensitivity
It also reduces the secretion of free fatty acids and resistin , thus improving insulin resistance at its root.
Dual benefits confirmed by clinical data
|
index |
Effects of monotherapy at 52 weeks |
Compared with traditional drugs |
|
HbA1c decrease |
0.8%-1.2% |
Superior to glimepiride by 0.5% |
|
weight change |
-1.5~3kg |
Sulfonylureas cause a weight gain of 2-3 kg |
|
Blood sugar fluctuations |
Shrink by 42% |
Fluctuations increased by 30% in the insulin group. |
03 Triple Enhancement Solution: Accelerates Fat Burning
Diet Restructuring – Eat Your Fill and Still Lose Weight
Resistant starch substitution method :
Replace the white rice with cooled black rice/whole wheat pasta :
Postprandial blood glucose peak decreased by 30% , and GLP-1 secretion increased by 40%.
Protein leverage strategy:
Daily protein intake ≥1.2g/kg body weight (72g for a 60kg individual):
High-protein diet → Activates liver gluconeogenesis → Increases daily metabolic rate by 200kcal
A practical one-day menu :
Breakfast : 50g oat bran + 3 egg whites + 200g broccoli (to activate GLP-1)
Snack : 30g braised beef + 10 almonds (to maintain muscle metabolism)
Fragmented exercise – painless fat burning
Accumulate 30 minutes of "micro-exercise" daily:
● Squat against a wall for 3 minutes after meals : Lower limb muscle contraction accelerates glucose uptake.
● Watch TV while rowing with an elastic band for 10 minutes : Strengthens back muscles and increases basal metabolism.
● 12-minute bedtime yoga : Improves insulin sensitivity
Golden Drug Partner
Trelagliptin 100mg/week + Metformin 1000mg/day :
● Trelagliptin: Enhances GLP-1 activity and promotes precise insulin secretion.
● Metformin: Inhibits hepatic glucose output and improves insulin resistance.
→ Clinical weight loss results are twice as effective (average 3-5 kg/6 months).
04 Real Transformation: From Metabolic Disorder to a Lighter Figure
Mr. Wu's case (49 years old, 6-year course of illness)
● Original treatment plan : Glimepiride + insulin, weight increased from 70kg to 85kg
● Challenges : Waist circumference exceeds 100cm, fasting blood glucose fluctuates between 8-12mmol/L
● New plan :
Trelagliptin 100mg/week
Metformin 850mg twice daily
High-protein + resistant starch diet
Daily Fragmented Exercise
● 16 weeks later :
✓ Weight dropped to 76kg (a weight loss of 9kg)
✓ Waist circumference reduced by 12cm
✓ Fasting blood glucose is stable at 5.8-6.7 mmol/L
✓ Key breakthrough: No need for starvation therapy, lunch is still half a bowl of mixed grain rice.
05 Key Questions Answered
Is trelagliptin a weight loss drug?
It's not a dedicated weight-loss drug , but it creates the foundation for fat loss by achieving a " neutral or slightly negative weight " profile (avoiding the weight gain side effects of traditional medications). Actual weight loss still requires a daily calorie deficit of 300-500 kcal .
❓ Who will see more significant results in fat loss?
● Newly diagnosed type 2 diabetes patients (HbA1c 7%-8.5%)
● Those who gain more than 3 kg per year after using insulin/sulfonylureas
● Individuals with abdominal obesity and a BMI ≥ 28 (men with a waist circumference ≥ 90cm, women with a waist circumference ≥ 85cm)
❓ Is it necessary to strictly count calories?
No need for precise calculations, just master the "One Palm Rule" :
● Staple food ≤ 1 palm-sized portion
● Protein content ≥ 1 palm-sized amount
● Vegetables piled up in both hands
Start a metabolic revolution for a healthy body
The value of trelagliptin succinate tablets lies not only in the freedom of once-weekly medication , but also in its ability to rewrite the dilemma of diabetes treatment where " blood sugar control inevitably leads to weight gain ." When combined with a high-protein diet, resistant starch, and fragmented exercise , it forms a "golden triangle" for overcoming lipid metabolism disorders.
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⚠️ Friendly reminder: This article is for reference only. Please consult your doctor for specific medication advice.
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🛒Takeda Tragliptin Succinate Tablets, DPP-4 Inhibitor, 50mg, 20 tablets
🛒Takeda Tragliptin Succinate Tablets, a DPP-4 inhibitor, 100mg in 20 tablets