Daridorexant 25mg is a new drug for the treatment of sleep disorders.

Product Information

• Japanese name : クービック町
• English Name : Daridorexant Tablets
• Chinese name : Dali Leisheng Tablets
• Generic name : クービビック tablets 25mg / クービビック tablets 50mg
• Product specifications :
• クービビック tablets 25mg : 100 tablets ( PTP 10 tablets × 10 )
• クービビック tablets 50mg : 100 tablets ( PTP 10 tablets × 10 )
• Manufacturer : Shionogi Sesame Co., Ltd.
• Shipping method : Direct mail from Japan

Indications

It is suitable for adult insomnia patients who have difficulty falling asleep and / or maintaining sleep. It can effectively improve insomnia problems such as difficulty falling asleep and waking up easily at night, and help patients restore their normal sleep rhythm.

Mechanism of action

As a dual orexin receptor antagonist, it blocks the binding of orexin to the receptor, inhibits the wakefulness-promoting effect, induces physiological sleep, and allows you to naturally enter a deep sleep state.

Dosage

• Recommended dose : The usual dose for adults is 50 mg , once a night before bed.
• Adjust the dose : Depending on the patient's condition, the dose can be adjusted to 25 mg under the guidance of a doctor.
• Dosage time : Please take it before bedtime and make sure you have at least 7 hours of sleep after taking the medicine.
• Note : Avoid taking with food to avoid affecting the efficacy of the drug.

Precautions

• Special populations : Pregnant and lactating women, children and elderly patients must use the product under the strict guidance of a doctor.
• Contraindications : It is contraindicated in patients who are allergic to the ingredients of this product and patients with severe liver dysfunction.
• Driving and hazardous activities : Taking the drug may affect the ability to stay awake during the day. It is prohibited to drive or engage in activities that require a high level of mental alertness.
• Drug interactions : Do not take it with other central nervous system depressants (such as benzodiazepines) or alcohol to avoid enhancing the efficacy or causing adverse reactions.

Common side effects

• Nervous system : drowsiness, headache, dizziness, sleep paralysis, etc.
• Digestive system : nausea, dry mouth, etc.
• Mental system : nightmares, hallucinations, abnormal sleep behavior (such as sleepwalking), etc.
• Others : burnout, fatigue, etc.

Pharmacokinetics

• Absorption : It is rapidly absorbed after oral administration, and food may affect its absorption rate and extent.
• Metabolism : Mainly metabolized by CYP3A enzymes in the liver.
• Excretion : Mostly in feces, a small amount in urine.

Considerations for special populations

• Patients with hepatic dysfunction : Patients with moderate hepatic dysfunction ( Child-Pugh classification B ) need to adjust the dose to 25 mg and use it with caution under the guidance of a physician.
• Elderly : The physiological functions of the elderly may decline, so they need to use the product under the guidance of a doctor.
• Pregnant and lactating women : Women who are pregnant or may become pregnant, or lactating women should use this drug with caution after their doctor has evaluated the benefits of treatment.

Packaging and storage

• Packaging : PTP packaging, 100 tablets per box ( 10 tablets × 10 ).
• Storage : Store in a cool, dry place, out of reach of children.

Kind tips

Please use this product strictly according to the doctor's prescription and pay attention to your body's reaction during use. If you feel any discomfort, please seek medical attention immediately.