Vortioxetine Hydrobromide 10mg 100 Tablets

Product Information

• Japanese name : Torotron
• English Name : Trintellix Tablets
• Chinese name : Tolinterix tablets
• Generic Name : Vortioxetine Hydrobromide
• Product specifications :
• Tolinterix Tablets 10mg
• Tolinterix Tablets 20mg
• Manufacturer : Takeda Pharmaceutical Company Limited
• Shipping method : Direct mail from Japan

Indications

Suitable for the treatment of depression and related symptoms.

Mechanism of action

Tolinterix is ​​a multimodal antidepressant that works through the following mechanisms:

• Selective serotonin reuptake inhibition : inhibits the reuptake of serotonin ( 5-HT ) and increases the concentration of 5-HT in the synaptic cleft.
• 5- HT receptor regulation : It has an antagonistic effect on 5-HT3 and 5-HT7 receptors, a partial agonist effect on 5-HT1B receptors, and an agonist effect on 5-HT1A receptors.

Dosage

• Recommended dose : The usual initial dose for adults is 10 mg , once a day, orally. The dose can be appropriately adjusted within a range of no more than 20 mg depending on the patient's condition.
• Precautions : Avoid co-administration with CYP2D6 inhibitors (such as fluoxetine, quinidine), or when used in patients with hereditary CYP2D6 poor metabolizers, it is recommended to limit the dose to 10 mg .

Precautions

• Special groups : Pregnant women, lactating women, children and elderly patients should use it under the guidance of a doctor.
• Contraindications : Patients who are allergic to the ingredients of this product or who are currently using or have stopped using monoamine oxidase inhibitors ( MAOIs ) within 14 days are contraindicated.
• Driving and hazardous activities : Drowsiness, dizziness and other reactions may occur after taking the drug. Avoid driving or operating dangerous machinery.
• Drug interactions : Avoid co-administration with MAOIs , CYP2D6 inhibitors and other drugs.

Common side effects

• Nervous system : drowsiness, headache, dizziness.
• Digestive system : nausea, vomiting, diarrhea.
• Nervous system : insomnia, anxiety.
• Others : Fatigue, weight changes.

Pharmacokinetics

• Absorption : It is well absorbed after oral administration and food has no significant effect on its absorption.
• Metabolism : Mainly metabolized by the liver, involving multiple enzymes such as CYP2D6 and CYP3A4 .
• Excretion : Mainly through urine and feces.

Considerations for special populations

• Patients with Hepatic Dysfunction : Patients with moderate hepatic dysfunction may experience elevated blood drug concentrations and require dose adjustment.
• Elderly : The physiological functions of the elderly may decline, so the dosage needs to be adjusted with caution.
• Pregnant and breastfeeding women : Pregnant women should use the drug after weighing the pros and cons, and breastfeeding women should stop breastfeeding when using the drug.

Packaging and storage

• Packaging : PTP packaging, 100 pieces per box ( 10 pieces × 10 ).
• Storage : Store in sealed container, away from moisture and high temperature, and out of reach of children.

Kind tips

Please use this product strictly according to the doctor's prescription and pay attention to your body's reaction during use. If you feel any discomfort, please seek medical attention immediately.