Venlafaxine hydrochloride 37.5mg 100 tablets Depression Anxiety Venlafaxine hydrochloride

Product Information

• Japanese name : イフェクサーSRカプセル
• English Name : Effexor SR Capsules
• Chinese name : Venlafaxine Hydrochloride Sustained Release Capsules
• Generic name : Venlafaxine Hydrochloride
• Product specifications :
• イフェクサーSRカプセル37.5mg
• イフェクサーSRカプセル75mg
• Manufacturer : Viatris Pharmaceuticals
• Shipping method : Direct mail from Japan

Manufacturer

• Company name : Viatris Pharmaceuticals
• Address : 1-3-1 Azabudai , Minato-ku, Tokyo

Drug Type

• Category : Prescription Drugs
• Dosage form : sustained-release capsules
• Specification :
• イフェクサーSRカプセル37.5mg
• イフェクサーSRカプセル75mg

Indications

Used to treat depression and depression-related symptoms.

Contraindications

1. Patients who are allergic to the ingredients of this product.
2. Patients who are currently using or have stopped taking monoamine oxidase inhibitors ( MAOIs ) within 2 weeks.
3. Patients with severe hepatic impairment ( Child-Pugh classification C ).
4. Patients with severe renal impairment ( GFR ＜ 15mL/min ) or dialysis.

Dosage

• Adult Usage :
• Initial dose: 37.5 mg , once daily, after meals.
• Maintenance dose: can be gradually increased to 75 mg or higher based on tolerance, with a maximum dose not exceeding 225 mg/ day.
• Increment interval: at least 1 week.

Pharmacokinetics

• Absorption : It is well absorbed after oral administration and food has no significant effect on absorption.
• Metabolism : Mainly metabolized by the liver, metabolized by CYP2D6 and CYP3A4 .
• Excretion : Mainly through urine.

Pharmacological Action

• Mechanism of action : It exerts an antidepressant effect by inhibiting the reuptake of serotonin ( 5-HT ) and norepinephrine ( NE ), enhancing monoamine neurotransmission in the central nervous system.

Adverse Reactions

1. Common adverse reactions :
• Nausea, headache, dry mouth, insomnia, drowsiness, loss of appetite.
• Palpitations, increased blood pressure, constipation, dry mouth.
2. Serious adverse reactions :
• Suicidal thoughts or behavior (especially in patients younger than 24 years).
• Liver dysfunction, hyperglycemia, hypertensive crisis.
• Psychiatric symptoms (eg, hallucinations, aggression).

Precautions

1. Special Populations :
• Pregnant and lactating women : Use with caution after a physician has evaluated the therapeutic benefit.
• Elderly : Use under the guidance of a doctor and pay attention to dosage adjustment.
• Children : Not applicable (patients under 18 years of age require careful evaluation).
2. Driving and hazardous activities : The drug may affect concentration and reaction ability after taking it, so avoid driving or operating machinery.
3. Drug interactions : Avoid co-administration with MAOIs , CYP2D6 inhibitors (such as paroxetine) and other drugs to avoid enhancing the efficacy or causing adverse reactions.

Packaging and storage

• Packaging : PTP packaging, 100 capsules per box ( 10 capsules × 10 ).
• Storage : Store in sealed container, avoid high temperature and humidity environment, and prevent children from accidentally ingesting.