Carpronium Chloride Topical Solution 5% "CH" 30mL×12 (This appears to be a product description for a topical application of carpronium chloride, possibly for alopecia, dry seborrhea, or vitiligo.)

Calpronium Chloride Topical Solution 5% "CH" is a quaternary ammonium salt topical antibacterial disinfectant, with calpronium chloride as its main component. This drug exerts a broad-spectrum antibacterial effect by disrupting the cell membranes of microorganisms, and is effective against a variety of bacteria, fungi, and some viruses. It is suitable for the adjunctive treatment of superficial skin and mucous membrane infections and for preoperative disinfection, such as small wounds, abrasions, and folliculitis.

I. Basic Drug Information

1. Common name: Cappronium chloride
2. English name: Carpronium Chloride Solution
3. Product name: Carpronium Chloride External Solution 5% "CH" (Carpronium Chloride External Solution 5% "CH")
4. Dosage form: External liquid
5. Indications:
   • Hair removal prevention and hair growth promotion for alopecia (including circular alopecia, multiple circular alopecia, malignant alopecia, pityriasis alopecia, diffuse alopecia, senile alopecia, symptomatic alopecia, etc.);
   • Dry seborrheic dermatitis;
   • Vitiligo vulgaris.
6. Element:
   • Active ingredient: 1 mL contains 50 mg of capreon chloride;
   • Additives: ethanol, sodium citrate, hydrochloric acid, yellow No. 4 (tar yellow), blue No. 1, and flavoring.
7. Appearance: A clear green liquid.

II. Usage and Dosage

• For alopecia and dry seborrhea: Apply an appropriate amount to the affected area 2-3 times a day, or sprinkle it on the entire hair-covered area and then gently massage.
• For vitiligo vulgaris: Apply an appropriate amount to the affected area 3-4 times a day.

III. Taboos

IV. Precautions

1. Special populations:
   • Patients with a history of allergy to any of the ingredients in this product should use it with caution.
   • Pregnant women: Use only when the treatment benefits outweigh the potential risks;
   • Breastfeeding women need to weigh the benefits of treatment against the nutritional value of breast milk and consider whether to continue breastfeeding.
   • Pediatrics: No clinical studies have been conducted in children;
   • Elderly individuals: Due to the decline in physiological functions, it is necessary to pay attention to reducing the dosage, etc.
2. Medication instructions:
   • For external use only. Avoid contact with eyes. If contact occurs, rinse immediately with water.
   • If you experience symptoms such as excessive sweating, chills, shivering, nausea, or vomiting after applying the medication, stop using the medication immediately and rinse the affected area with water.
   • Using the decoction afterward may worsen side effects; if side effects occur, the affected area should be rinsed.
3. Drug storage: Store at room temperature.

V. Adverse Reactions

1. Allergic reactions: transient redness and itching may occur (incidence rate 0.1%~5%).
2. Other reactions may include: irritation pain, local sweating, heat sensation, generalized sweating, and accompanying chills, shivering, nausea, and vomiting (frequency unknown).

VI. Drug Interactions

VII. Pharmacological effects

1. Local vasodilatory effect: its strength is about 10 times that of acetylcholine, and it is used to prevent hair loss, promote hair growth, and treat dry seborrhea and vitiligo.
2. Characteristics: It has good skin permeability, is resistant to cholinesterase, and has a long-lasting effect.

VIII. Pharmacokinetics

1. Absorption: When 1 mL of an alcohol solution containing 10 mg of capreon chloride (1/5 of the 5% concentration of this agent) was applied to the forearm of a healthy adult, the percutaneous absorption rate was 5.4% after 1 hour and 15.3% after 3 hours; it is biologically equivalent to 5% fluoropolymer topical solution, with similar percutaneous absorption rate.

IX. Clinical Research

1. Alopecia:
   • Domestic single-blind controlled trial: Apply to the affected area at least 4 times a day for 1 to 2 months or more, the effective rate for circular, multiple, malignant, and diffuse alopecia is 62.5% (25/40).
   • Domestic double-blind controlled trial: Apply to the affected area at least 3 times a day for more than 1 month (more than 1 week for pityriasis alopecia), the effective rate was 75.9% (66/87) for circular, multiple, malignant, and pityriasis alopecia.
2. common leukoderma:
   • Domestic single-blind controlled trial: Apply to the affected area at least 4 times a day for 1 to 2 months or more, with an efficacy rate of 45.0% (9/20).

10. Packaging Specifications

XI. Production Information

Manufacturer: Choseido Pharmaceutical Co., Ltd.