Shionogi Pharmaceutical Cymbalta Duloxetine Hydrochloride 20mg 100 Tablets Depression Diabetic Neuralgia Duloxetine Hydrochloride

Product Information

• Japanese name : サインバルタカプセル
• English Name : Cymbalta Capsules
• Chinese name : Duloxetine hydrochloride
• Generic name : Duloxetine
• Product specifications :
• サインバルタカプセル20mg
• サインバルタカプセル30mg
• Manufacturer : Shionogi & Co., Ltd.
• Shipping method : Direct mail from Japan

Manufacturer

• Company name : Shionogi & Co., Ltd.
• Address : 3-1-8 Doshucho , Chuo-ku, Osaka

Drug Type

• Category : Prescription Drugs
• Dosage form : Capsules
• Specification :
• サインバルタカプセル20mg
• サインバルタカプセル30mg

Indications

1. Treatment of depression and depressive states.
2. Pain caused by diabetic neuropathy.
3. Pain caused by fibromyalgia, chronic low back pain, and osteoarthritis.

Contraindications

1. Patients who are allergic to the ingredients of this product.
2. Patients who are currently using or have stopped taking monoamine oxidase inhibitors ( MAOIs ) within 2 weeks.
3. Patients with severe liver dysfunction.
4. Patients with severe renal impairment.
5. Patients with uncontrolled angle-closure glaucoma.

Dosage

• Depression and depressive states :
• Initial dose: 20 mg , once daily, after meals.
• Maintenance dose: can be gradually increased to 40mg or 60mg , the maximum dose should not exceed 60mg/ day.
• Diabetic neuropathy pain :
• Initial dose: 20 mg , once daily, after meals.
• Maintenance dose: can be gradually increased to 40mg or 60mg , the maximum dose should not exceed 60mg/ day.
• Fibromyalgia, chronic low back pain, osteoarthritis pain :
• Initial dose: 20 mg , once daily, after meals.
• Maintenance dose: usually 60 mg/ day.

Pharmacokinetics

• Absorption : It is well absorbed after oral administration. Food may affect the absorption rate, but there is no significant difference in the overall absorption amount.
• Metabolism : Mainly metabolized by CYP1A2 and CYP2D6 in the liver.
• Excretion : Mostly excreted in the form of metabolites through urine and feces.

Pharmacological Action

• Mechanism of action : It inhibits the reuptake of serotonin ( 5-HT ) and norepinephrine ( NE ), enhances monoamine neurotransmission in the central nervous system, and exerts antidepressant and analgesic effects.
• Pharmacological Action : Shows antidepressant, anxiolytic and analgesic effects in animal models.

Adverse Reactions

1. Common adverse reactions :
• Nausea, dry mouth, constipation, headache, dizziness, drowsiness, insomnia.
• Thirst, loss of appetite, sexual dysfunction.
2. Serious adverse reactions :
• Suicidal thoughts or behavior (especially in patients younger than 24 years).
• Liver dysfunction, hyperglycemia, hypertensive crisis.
• Psychiatric symptoms (eg, anxiety, aggression, hallucinations).

Precautions

1. Special Populations :
• Pregnant and lactating women : Use with caution after a physician has evaluated the therapeutic benefit.
• Elderly : Use under the guidance of a doctor and pay attention to dosage adjustment.
• Children : Not applicable (patients under 18 years of age require careful evaluation).
2. Driving and hazardous activities : The drug may affect concentration and reaction ability after taking it, so avoid driving or operating machinery.
3. Drug interactions : Avoid co-administration with MAOIs , CYP2D6 inhibitors (such as paroxetine) and other drugs to avoid enhancing the efficacy or causing adverse reactions.

Packaging and storage

• Packaging : PTP packaging, 100 capsules per box ( 10 capsules × 10 ).
• Storage : Store in sealed container, avoid high temperature and humidity environment, and prevent children from accidentally ingesting.